The relationship between individual alpha peak frequency and clinical outcome with repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)

Brain Stimulation
Juliana CorlierAndrew F Leuchter

Abstract

The individual α frequency (IAF) has been associated with the outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD), but the association has been inconsistent. Proximity of IAF to the stimulation frequency, rather than the value of IAF per se, is associated with outcome for patients receiving 10 Hz rTMS. We examined the relationships between IAF, rTMS stimulation frequency, and treatment outcome in 147 patients. All patients initially received 10 Hz rTMS unilateral treatment delivered to left dorsolateral prefrontal cortex (DLPFC) (10UL), with subsets of patients changed to unilateral 5 Hz to left DLPFC (5UL) or sequential bilateral (SB) stimulation (10 Hz/1Hz) to left and right DLPFC based upon worsening symptoms with or intolerance of 10UL. Outcome was percent change in total score on the Inventory of Depressive Symptomatology - Self Report (IDS-SR) scale from pre-treatment baseline to the 30th treatment. IAF values and absolute difference between IAF and 10 Hz (|IAF-10Hz|) were examined in relation to outcome for the overall sample and for each stimulation group separately. There was no correlation between IAF value, or |IAF-10Hz| and outcome in the overall sample. ANCOVA...Continue Reading

Citations

Nov 24, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Neil W BaileyPaul B Fitzgerald
Nov 28, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Charlotte L RoelofsMartijn Arns
Jan 3, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sebastian Olbrich, Martin Brunovsky
Apr 8, 2021·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Nicholas MurphySanjay J Mathew
May 19, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Adam M ChekroudKarmel Choi

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