PMID: 9536955Apr 16, 1998Paper

The relationship between intrahepatic portal systemic shunts and microsphere induced portal hypertension in the rat liver

Gut
X LiBarry Alexander

Abstract

Portal hypertension is associated with gross haemodynamic disturbances characterised by high cardiac output, low peripheral vascular resistance, increased splanchnic blood flow, and portal systemic shunting. To study the relationship between intrahepatic portal systemic shunts and microsphere induced portal hypertension in the rat liver. Different sized microspheres were sequentially injected into the portal vein of male Wistar rats. Steady state portal venous pressure was increased by 102.2 (35.6)% (14.9 (3.6) mm Hg) and 272.3 (78.0)% (24.0 (2.2) mm Hg) above the basal pressure following sequential injections of 15 and 80 microns diameter microspheres, respectively. Sequential injection of 15, 40, and 80 microns diameter microspheres in either ascending or descending order of size did not generate further increases in portal venous pressure. A single injection of 1.8 x 10(5) 80 microns microspheres consistently produced a steady state portal venous pressure of 19.0 (1.3) mm Hg but did not approach the much higher value of 36.6 (43.2) mm Hg measured during clamping of the portal vein. These data indicate that the opening of patent intrahepatic shunts was responsible for the reduced pressures observed during microsphere injectio...Continue Reading

References

Nov 1, 1986·Seminars in Liver Disease·P M HuetA Viallet
Nov 1, 1986·Seminars in Liver Disease·J BoschJ Rodés
Jan 1, 1973·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A O Myking, J F Halvorsen

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Citations

May 20, 1998·Nutrition·B Alexander
May 25, 2010·Journal of Gastroenterology and Hepatology·Wangxun JinJianmin Li
May 28, 2011·Journal of Gastroenterology and Hepatology·Masayuki MiyazakiRyoichi Takayanagi
Jul 29, 2006·Orphanet Journal of Rare Diseases·Christophe Chardot
Jan 5, 2011·Research in Veterinary Science·R W Furneaux
Nov 18, 1998·Journal of Microencapsulation
Dec 14, 2018·Experimental and Therapeutic Medicine·Guijun RenQiang Zeng
Jan 19, 2005·World Journal of Gastroenterology : WJG·Xiang-Nong LiBarry Alexander

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