PMID: 7083323Jan 1, 1982Paper

The relationship between left ventricular functional response to isometric exercise and asynergic contraction and diastolic stiffness

Catheterization and Cardiovascular Diagnosis
P A LudbrookA J Tiefenbrunn

Abstract

Either augmentation or impairment of left ventricular function has previously been reported in different patients, in response to isometric exercise. To identify the mechanisms associated with these disparate responses, the effects of submaximal sustained handgrip upon left ventricular systolic and diastolic properties were studied in 29 patients during diagnostic catheterization. In 16 patients (group I), ejection fraction, mean Vcf, and the mean systolic ejection rate remained constant, while the ratio of peak systolic pressure to end systolic volume increased significantly from 2.81 +/- 0.6 to 3.17 +/- 0.6 ml/mm Hg. In 13 patients (group II) ejection fraction declined from 0.6 +/- 0.03 to 0.51 +/- 0.03, Vcf from 0.96 +/- 0.09 to 0.85 +/- 0.09 circ/sec, mean normalized systolic ejection rate from 1.79 +/- 0.1 to 1.50 +/- 0.09 sec-1, and the peak systolic pressure to end systolic volume ratio from 2.23 +/- 0.3 to 1.99 +/- 0.3 (p less than 0.05 for each). Systemic arterial mean pressure increased similarly by 19% and 21% in groups I and II, respectively (p less than 0.05 for each). Systemic vascular resistance increased significantly by 23% in group I and by 5% in group II (p less than 0.05). Left ventricular end diastolic volu...Continue Reading

References

Feb 1, 1978·Circulation Research·S A Glantz, W W Parmley
Mar 1, 1976·Annals of Internal Medicine·W Grossman, L P McLaurin
Nov 1, 1977·The American Journal of Cardiology·K SagawaK M Bakalar
Sep 1, 1976·The Journal of Clinical Investigation·J L WeissM L Weisfeldt
Jan 1, 1976·Catheterization and Cardiovascular Diagnosis·R H HelfantV S Banka
Mar 1, 1973·Circulation·J Ross, K L Peterson
Sep 20, 1973·The American Journal of Cardiology·J W Covell, J Ross
Sep 1, 1974·The American Journal of Physiology·M L WeisfeldtW M Daggett
Jan 1, 1972·Cardiology·R E PattersonE C Peirce
Mar 1, 1973·The American Journal of Cardiology·K E Hammermeister, J R Warbasse
Jun 1, 1973·The American Journal of Cardiology·P A LudbrookR A O'Rourke
Jan 1, 1974·The American Journal of Cardiology·P A LudbrookR A O'Rourke
Sep 1, 1971·Circulation Research·G DiamondH J Swan
Sep 1, 1966·The American Journal of Cardiology·H R MacDonaldK W Donald

Citations

May 30, 2009·The Tohoku Journal of Experimental Medicine·Hisashi MasugataFuminori Goda
Sep 1, 1983·The American Journal of Cardiology·H V Huikuri, J T Takkunen
Sep 1, 1984·The American Journal of Cardiology·H V HuikuriJ T Takkunen

Related Concepts

Diastolic Blood Pressure
Coronary Heart Disease
Cardiac Catheterization Procedures
Left Ventricular Structure
Isometric Contraction
Myocardial Contraction
Stroke Volume

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