The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review

Nutrients
Yu Qi LeeKirsty G Pringle

Abstract

The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring kidney structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria. Nutrients reviewed to date included vitamin A (n = 3), folate and vitamin B12 (n = 2), iron (n = 1), vitamin D (n = 1), total energy (n = 2) and protein (n = 1). Seven studies were assessed as being of "positive" and three of "neutral" quality. A variety of populations were studied, with limited studies investigating maternal nutrition during pregnancy, while measurements of offspring kidney outcomes were diverse across studies. There was a lack of consistency in the timing of follow-up for offspring kidney structure and/or function assessments, thus limiting comparability between studies. Deficiencies in m...Continue Reading

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Citations

Dec 4, 2019·NeoReviews·Amanda Dyson, Alison L Kent
Mar 27, 2019·Nutrients·Sabina Bastos MaiaMalaquias Batista Filho
Oct 2, 2020·Current Developments in Nutrition·Bryan M GannonSaurabh Mehta
Apr 22, 2021·Expert Review of Endocrinology & Metabolism·Sonali MalhotraFatima Cody Stanford
Jan 22, 2021·Public Health Nutrition·Sorayya Kheirouri, Mohammad Alizadeh

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