The Relationship Between MRI Signal Intensity Changes, Clinical Presentation, and Surgical Outcome in Degenerative Cervical Myelopathy: Analysis of a Global Cohort

Spine
Aria NouriMichael G Fehlings

Abstract

Retrospective analysis of prospective data. To assess the relationship between MRI signal intensity changes, clinical presentation, and surgical outcome in degenerative cervical myelopathy (DCM). Several studies have sought to assess the extent of spinal cord dysfunction and the potential for postoperative neurological recovery through the evaluation of spinal cord signal change on T2-weighted (T2WI) and T1-weighted images (T1WI). There remains ambiguity if T2WI and T1WI signal changes (1) relate to baseline severity, and (2) predict neurological recovery after surgical treatment. Four hundred nineteen MRIs from two prospective multicenter studies were examined. Images were assessed for the presence, levels, and location of spinal cord signal intensity changes and compared with clinical data. Signal changes were also evaluated for the prediction of 2-year postoperative outcome using mJOA parameters. MRIs were categorized by T1WI and T2WI signal change: no signal change (28.9%), T2WI hyperintensity-only (T2WI-only, 51.8%), and T2WI-hyperintensity and T1WI-hypointensity (T1WI+T2WI, 19.3%). T2WI-hyperintensity was present at multiple levels in 27% of patients overall. Baseline severity increased from no signal change to T2WI-only ...Continue Reading

References

Sep 27, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·T AlafifiM Fehlings
Aug 29, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Aditya Vedantam, Vedantam Rajshekhar
Feb 7, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Lindsay A TetreaultMichael G Fehlings
Mar 15, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Spyridon K KaradimasMichael G Fehlings
Jun 17, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hatem M I SalemZdenek Klezl
Jul 15, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jing Tao ZhangYong Shen

❮ Previous
Next ❯

Citations

Oct 10, 2018·Journal of Medical Internet Research·Benjamin Marshall DaviesMark Rn Kotter
Jun 26, 2018·Clinical Spine Surgery : a Spine Publication·Barrett S BoodyChristopher K Kepler
Jul 17, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Małgorzata MańczakRobert Gasik
Aug 31, 2019·Journal of Veterinary Internal Medicine·Marília de Albuquerque Bonelli, Ronaldo C da Costa
Nov 16, 2019·Journal of the American Veterinary Medical Association·Marilia de A Bonelli, Ronaldo C da Costa
Mar 15, 2020·Journal of Clinical Medicine·Rocco SeverinoEnrico Tessitore
Jun 18, 2020·Journal of Clinical Medicine·Stefania d'AvanzoGualtiero Innocenzi
Jan 25, 2020·Nature Reviews. Neurology·Jetan H BadhiwalaMichael G Fehlings
Apr 1, 2020·JBJS Reviews·Nicholas ShepardAfshin Razi
Apr 9, 2021·BMC Veterinary Research·Marília de Albuquerque BonelliRonaldo Casimiro da Costa
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Neurological ImagingAmanda S Corey
Jun 6, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Joon Bum YeoHeung Sik Kang
Aug 10, 2021·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Marília de Albuquerque BonelliRonaldo Casimiro da Costa
Aug 28, 2021·Journal of Clinical Medicine·Melissa Lannon, Edward Kachur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.