The relationship between nerve terminal adenosine triphosphatases and neurotransmitter release: as determined by the use of antidepressant and other CNS-active drugs

British Journal of Pharmacology
J C Gilbert, M G Wyllie

Abstract

1 The role of adenosine triphosphatases (ATPases) in neurotransmitter release was studied using nerve terminals (synaptosomes) prepared from rat cerebral cortex as a model. 2 Amitriptyline, nortriptyline, protriptyline, desipramine and imipramine were found to inhibit ATPases at concentrations of 10(-5) M and above. The drugs inhibited both the basal and electrically evoked release of acetylcholine (ACh) and noradrenaline (NA) at concentrations of 10(-4) M and above. 3 At low concentrations of antidepressants (10(-8) and 10(-7) M) release of NA was enhanced but there was no effect on ACh release. 4 Other drugs which inhibit Na+, K+-ATPase increase basal NA release as did drugs which inhibited vesicular MG2+-ATPase. 5 A model is proposed suggesting that transmitter release/re-uptake depends on (1) active Na+, K+-ATPase at the presynaptic membrane and (2) an active synaptic vesicular MG2+-ATPase.

References

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Citations

Jan 8, 1982·European Journal of Pharmacology·N J RothwellM G Wyllie
Nov 1, 1981·British Journal of Pharmacology·N J RothwellM G Wyllie
Feb 1, 2012·Biological Psychiatry·Nina B L UrbanAnissa Abi-Dargham
Jun 1, 1983·Journal of Autonomic Pharmacology·D A Powis
Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M D Wood, M G Wyllie
Jan 1, 1982·The Journal of Pharmacy and Pharmacology·M G WyllieJ Fox

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