PMID: 9661889Jul 14, 1998Paper

The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer

Cancer Research
R HeimannS Hellman

Abstract

Distant metastases are the major cause of morbidity and mortality in women with breast cancer. The prediction of this metastatic proclivity is essential in determining prognosis and should allow an appropriate choice of therapy. A critical look at the metastatic process and its phenotypic expression offers an opportunity to identify some of the important events in the process that may relate to prognosis, with the goal of identifying those patients with occult metastases and also sparing systemic treatment in those patients whose tumors have not developed the capacity for distant spread. To evaluate the significance of nm23 and angiogenesis in the metastatic cascade, we used archival material from 163 node-negative breast cancer patients who had a median follow-up of 14 years. All patients underwent mastectomy and received no adjuvant chemotherapy or hormone or radiation therapy. Immunohistochemistry was used to detect nm23-H1 expression, whereas angiogenesis was determined by microvessel count (MVC). We found the 15-year disease-free survival (DFS) to be significantly better in patients with high nm23 compared with low nm23 (91% compared with 70%, P = 0.008). Low MVC is associated with excellent (92%) long-term DFS. In those p...Continue Reading

Citations

Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·O WatanabeT Kajiwara
Dec 14, 2004·Journal of Cancer Research and Clinical Oncology·Andreas M StarkJanka Held-Feindt
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Heimann, S Hellman
Mar 15, 2001·Critical Reviews in Oncology/hematology·H H Sedlacek
Jan 29, 2011·Journal of Virology·Zhiqiang QinChris Parsons
Mar 16, 2002·Journal of Clinical Pathology·Alastair N J GrahamJ A McGuigan
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia S SteegKathy D Miller
Sep 20, 2005·Breast Cancer Research : BCR·Ingrid LjuslinderRoger Henriksson
Nov 9, 2006·Virchows Archiv : an International Journal of Pathology·Kelen Christine do NascimentoAdriano Mota Loyola
Nov 18, 2011·Cancers·Iain L O Buxton, Nucharee Yokdang
Aug 3, 2002·Oncogene·Martin Widschwendter, Peter A Jones

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