PMID: 15379636Sep 24, 2004Paper

The relationship between oncogene expression and clinical outcome in endometrial carcinoma

Current Cancer Drug Targets
Noriyuki TakaiIsao Miyakawa

Abstract

The mechanism of oncogenesis is extremely complicated and controlled by various factors, most of which are based on cell proliferation, tumor invasion, neovascularization, and inhibition of apoptosis. We have investigated the relationship between thirty three oncogenes expression and histopathological prognostic factors of endometrial carcinomas, including clinical stage, histological grade, presence of invasion to greater than one-half the myometrium, clinical outcome, and survival rate. Scoring on the basis of the percentage of positive cells indicated that Plks, EphB4, ephrin-B2, Id1, CaMKIV, c-Ets1, Elf-1, and survivin expression were significantly associated with PCNA-labeling index, clinical stage, histological grade, the presence of invasion to greater than one-half the myometrium, and clinical outcome. Survival data were available for all patients, and univariate Cox regression analysis showed that Plks, CaMKIV, Elf-1, and survivin expression were significantly associated with poor prognosis. Our results demonstrate that some oncogenes expression in endometrial carcinoma correlate with the malignant potential of these tumors. Thus, in addition to being of diagnostic value, modulation of these oncogenes activity in the t...Continue Reading

Citations

Jun 11, 2005·Cell and Tissue Research·Andrew J RyanMartin K Oehler
Nov 5, 2014·Leukemia & Lymphoma·Monica TestoniFrancesco Bertoni
Dec 7, 2007·The Journal of Steroid Biochemistry and Molecular Biology·A DollJ Reventós
Jul 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M TachibanaH Yoshimura
Oct 13, 2006·Gynecologic Oncology·Serkan ErkanliEsra Kuscu
Feb 4, 2006·Molecular Human Reproduction·Cherie A KesslerStuart Handwerger
May 26, 2021·NPJ Breast Cancer·Paulina M WojnarowiczRobert Benezra

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