The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis

European Journal of Endocrinology
Ihsan AtesSerdar Güler

Abstract

We have aimed to study the relation between Hashimoto's thyroiditis (HT) and thyroid autoantibodies and oxidative stress parameters in euthyroid, subclinical and overt hypothyroid stages. A total of 124 patients were included in the study; 93 of whom were newly diagnosed with HT (31 patients in each of the euthyroid, subclinical hypothyroid and overt hypothyroid subgroups), aged over 18 and had not received any prior treatment and 31 of whom were healthy volunteers. Total oxidant status (TOS) and oxidative stress index (OSI) levels were higher, and total antioxidant status (TAS) and total thiol and arylesterase levels were lower in the overt hypothyroid group compared to other groups. TOS and OSI levels increased, and TAS levels decreased significantly in each phase from euthyroid, subclinical hypothyroid, to overt hypothyroid subgroups among HT patients. There was a negative correlation between TAS, log (paraoxonase1) and paraoxonase1/HDL and anti-thyroid peroxidase and a negative correlation between anti-thyroglobulin and total thiol. It was also determined that overt hypothroidism was an individual predictor that effects all of the oxidative stress parameters, but not total thiol, levels. Our results suggest that oxidative s...Continue Reading

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Citations

Jan 24, 2016·Thyroid : Official Journal of the American Thyroid Association·Anne Nm McGowanJames Gibney
Feb 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Rosaria M RuggeriSebastiano Gangemi
Mar 10, 2016·European Journal of Endocrinology·Ihsan AtesSerdar Guler
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Jul 9, 2020·Journal of Clinical Medicine·Katarzyna MorawskaAnna Zalewska
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Aug 8, 2021·International Journal of Environmental Research and Public Health·Joanna SzczepanikKatarzyna Domaszewska

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