PMID: 9176967May 1, 1997Paper

The relationship between parameters of serotonin metabolism and emetogenic potential of platinum-based chemotherapy regimens

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
A du BoisH Kriesinger-Schroeder

Abstract

Evaluation of the relationship between parameters of serotonin (5-HT) metabolism and emesis in platinum-based chemotherapy. Female patients receiving chemotherapies containing either cisplatin (35 patients; 80 courses) or carboplatin (65 patients; 102 courses) were recruited. Recording of emesis and measurements of urinary 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of 5-HT, was performed over 3 days. Comparisons were performed for single-agent cisplatin (DDP) versus single-agent carboplatin (CBDCA), single-agent high-dose DDP (> or = 75 mg/m2) versus high-dose DDP combined with cyclophosphamide, high-dose versus low-dose DDP (< or = 50 mg/m2), and single-agent CBDCA versus a combination with alkylating agents. Cisplatin induced both a significantly higher frequency of emesis and a significantly higher increase of 5-HIAA excretion than carboplatin. The velocity of 5-HIAA increase may correlate better with emetogenic potential than peak 5-HIAA excretion levels. The increase of 5-HIAA excretion induced by cisplatin was limited to day 1. Higher cisplatin doses showed both a higher emetogenic potential and a more pronounced increase in urinary 5-HIAA on day 1. No significant difference was found when single-agent cispl...Continue Reading

Citations

Jul 21, 2011·International Journal of Clinical Oncology·Yuichiro HiuraYuichiro Doki
Jul 17, 2008·Supportive Cancer Therapy·Nancy Price, Vinay K Jain
Aug 9, 2008·Neuropharmacology·Robin Spiller
Dec 13, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Gerald M HigaKenneth Landreth

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