The relationship between pentosidine and hemodialysis-related connective tissue disorders

Nephron
S SakataT Inoue

Abstract

Dialysis-related amyloidosis (DRA), such as destructive spondyloarthropathy (DSA) and carpal tunnel syndrome (CTS), occurs in the connective tissues of patients on long-term hemodialysis (HD). Recently, it was suggested that advanced glycation end products (AGEs) and beta2-microglobulin (beta2m) modified with AGEs are related to DRA. The aim of this study is to elucidate whether serum levels of pentosidine, which is an AGE, relate to the occurrence of DRA in patients with long-term HD. 127 end-stage renal failure patients, with DSA or CTS and undergoing HD, were examined. Serum pentosidine was measured by the HPLC method with column switching. Beta2m and intact parathyroid hormone (i-PTH) were measured. Pentosidine levels were significantly elevated in the DSA, CTS, and DRA groups (patients in the DRA group had either DSA and/or CTS). There were no significant differences in the beta2m and i-PTH levels between any group. The duration of HD did not correlate with either pentosidine or beta2m levels, but did with i-PTH. Receiver-operating characteristic (ROC) analysis was performed to examine the discriminatory ability of pentosidine, beta2m, and i-PTH for DRA. The area under the ROC curve was the greatest for pentosidine. Serum ...Continue Reading

Citations

Jun 5, 2003·Analytical Biochemistry·Masashi AbeAkira Nagano
Mar 21, 2002·European Journal of Clinical Investigation·G GlorieuxN Lameire
Feb 3, 2005·Journal of Spinal Disorders & Techniques·Yohei YuzawaSohei Ebara
Oct 22, 2004·Kidney International·Griet GlorieuxRaymond Vanholder
Apr 11, 2001·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·J M CampistolR Ramón
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Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Reng-Rong DaYiping Zhang

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