The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study.

The Journal of Clinical Endocrinology and Metabolism
Patricia C UnderwoodG H Williams

Abstract

Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists often cause volume retention and edema. A relationship between PPARgamma and renin may play a role in this process. The aim was to examine the relationship between the PPARgamma gene and plasma renin activity (PRA) levels in human hypertension. A candidate gene association study was conducted with two distinct groups of human participants: Caucasian hypertensives (n = 395) and African-American hypertensives (n = 55). Single nucleotide polymorphisms of the PPAR(Upsilon) gene were analyzed. Phenotype studies were conducted after participants consumed a low-salt diet (10 mmol/d) for 7 d and included PRA and aldosterone measurements before and after a 60-min angiotensin II infusion (3 ng/kg x min). Participants homozygous for the minor allele of rs2959272 (CC) had significantly higher PRA levels at baseline (P = 0.016) than major allele carriers (AA, AC) in Caucasian-hypertensive participants. The association of the C allele carrier status with increased PRA levels was replicated in the group of African-American hypertensive participants (P = 0.027). The Fisher's combined P value for both observations was significant (P = 0.002). These results demonstrate the fir...Continue Reading

Associated Clinical Trials

Sep 25, 2018·Gordon H. Williams, MD

References

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