PMID: 11903918Mar 21, 2002Paper

The relationship between propagated contractions and pseudoaffective changes in blood pressure in response to intestinal distension

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
A Timar-PeregrinJ B Furness

Abstract

We investigated the relationship between changes in small intestinal motility and changes in blood pressure and heart rate in response to intestinal distension. Rats were maintained under stable anaesthesia with alpha-chloralose, and jejunal motility, blood pressure and heart rate were recorded. Pressure changes during propagated contractions of the circular muscle were recorded in the jejunum when the intraluminal pressure was maintained at 10 mmHg. Raising the pressure in 10 mmHg increments from 10 mmHg to 40 mmHg increased the frequency of propagated contractions from 0.30 +/- 0.06 min-1 (mean +/- SEM) to 1.29 +/- 0.09 per min. In contrast, amplitudes of contractions above baseline pressure decreased from 19.5 +/- 0.6 mmHg to 7.8 +/- 0.5 mmHg. Simultaneously, blood pressure and heart rate were both increased. Pretreatment of rats with capsaicin, or severing the mesenteric nerves acutely, prevented these cardiovascular responses, but did not influence the changes in propagated activity caused by distension. Propagated contractions were blocked by hexamethonium (10 mg kg-1, intravenously [i.v.]) and by local application of 2% lidocaine, but propulsion was unchanged by hyoscine (1 mg kg-1, i.v.). Phentolamine (1 mg kg-1, i.v.) ...Continue Reading

References

May 1, 1990·Pain·T J Ness, G F Gebhart
Nov 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, G Skofitsch
Jun 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B FurnessJ C Bornstein
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·M Camilleri, M G Choi
May 20, 1998·European Journal of Pharmacology·P G McLeanL Buéno
Jun 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H YamamotoM Fujimiya
Feb 29, 2000·British Journal of Pharmacology·M ToulouseL Buéno
Oct 12, 2001·Autonomic Neuroscience : Basic & Clinical·B Folkow
May 11, 1899·The Journal of Physiology·W M Bayliss, E H Starling
Jun 30, 1904·The Journal of Physiology·R S Woodworth, C S Sherrington

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Citations

Apr 15, 2006·Digestive Diseases and Sciences·Diana GentilcoreKaren L Jones
Apr 25, 2007·Scandinavian Journal of Gastroenterology·Clinton NgJohn Kellow
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M RömerP Holzer
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G BogeskiJ B Furness
Jul 9, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G BogeskiJ B Furness
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A D ShaftonJ B Furness
Apr 3, 2004·Physiology & Behavior·Rianne StamVictor M Wiegant

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