PMID: 172983Oct 1, 1975

The relationship between prostaglandin release and lung c-AMP levels during anaphylaxis in the guinea-pig

Prostaglandins
K J Barrett-Bee, L R Green

Abstract

A four-fold transient rise in c-AMP levels was seen when sensitized guinea-pig lungs were challenged with antigen in vitro. This rise in c-AMP also occurred in vivo and was shown to be due to release of Prostaglandin E2. This conclusion is supported by the finding that inhibitors of prostaglandin synthesis (Indomethacin and Poly phloretin phosphate) prevent the rise in c-AMP while neither ICI 74, 917, an inhibitor of histamine release, nor antihistamines had any effect on the c-AMP levels.

References

Sep 1, 1972·The Journal of Experimental Medicine·M KalinerK F Austen
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Jan 1, 1973·International Archives of Allergy and Applied Immunology·W Schmutzler, R Derwall
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·W BernauerP Filipowski
Apr 10, 1974·Prostaglandins·E YoussefnejadianI Craft

Citations

Nov 1, 1976·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E W Peterson, R Leblanc

Related Concepts

Cyclic AMP, (R)-Isomer
Anaphylaxis
Burimamide
Cavia porcellus
Ceplene
Variolation
Osmosin
Novodrin
Lung
Ovalbumin

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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