The relationship between prostate-specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate-specific antigen levels.

The Prostate
Kouji IzumiMikio Namiki

Abstract

Prostate-specific antigen (PSA) is a useful biomarker for risk classification in patients with prostate cancer. However, it is unclear whether a correlation exists between low PSA levels (<10 ng/ml) at diagnosis and prognosis. Of the 642 Japanese patients who underwent prostate biopsy and were diagnosed with prostate cancer at Kanazawa University Hospital from 2000 to 2010, 406 patients with a PSA level <20 ng/ml were retrospectively reviewed. PSA levels in 275 (68%) patients were <10 ng/ml. Although the percentage of Gleason score 8-10 in patients with a PSA level of <3.5 ng/ml was higher than that in patients with a PSA level between 3.5 and 10 ng/ml, it was not statistically significant. On the other hand, the percentage of higher stage (T3 and T4) patients with a PSA level <3.5 ng/ml was significantly greater than that in patients with a PSA level between 3.5 and 10 ng/ml (P < 0.0001). The percentage of metastases (N1 and M1) in patients with a PSA level <3.5 ng/ml was also significantly higher than that in patients with a PSA level between 3.5 and 10 ng/ml (P = 0.0112). Patients with prostate cancer with a PSA level <3.5 ng/ml at diagnosis had a more advanced stage of cancer compared with those with a PSA level between 3.5...Continue Reading

References

Feb 25, 2000·The Journal of Urology·F H SchröderR Kranse
May 26, 2009·Steroids·Irina U Agoulnik, Nancy L Weigel
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Oct 25, 2011·BJU International·Barry B McGuireWilliam J Catalona
Dec 12, 2012·The New England Journal of Medicine·Charles J RyanUNKNOWN COU-AA-302 Investigators
Jul 19, 2013·The New England Journal of Medicine·C ParkerUNKNOWN ALSYMPCA Investigators
Nov 13, 2013·Anti-cancer Drugs·Ovidio FernándezLuis M Antón Aparicio
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 22, 2014·Journal of Cancer Research and Clinical Oncology·Kouji IzumiMikio Namiki
Jun 3, 2014·The New England Journal of Medicine·Tomasz M BeerUNKNOWN PREVAIL Investigators
Oct 30, 2014·The New England Journal of Medicine·Tomasz M Beer, Bertrand Tombal

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Citations

Feb 18, 2017·Scientific Reports·Kazutoshi FujitaNorio Nonomura
Aug 20, 2016·Clinical Chemistry·Farhana MatinJyotsna Batra
Oct 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yan XuZhi Guo
Dec 7, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hiroaki IwamotoAtsushi Mizokami
Mar 8, 2021·Talanta·André MirandaCarla Cruz

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