The relationship between proteinuria and allograft survival in patients with transplant glomerulopathy: a retrospective single-center cohort study.

Transplant International : Official Journal of the European Society for Organ Transplantation
Qiang ZhangKlemens Budde

Abstract

Proteinuria and transplant glomerulopathy (TG) are common in kidney transplantation. To date, there is limited knowledge regarding proteinuria in different types of TG and its relationship to allograft survival. A retrospective cohort analysis of TG patients from indication biopsies was performed to investigate the relationship of proteinuria, histology, and graft survival. One hundred and seven (57.5%) out of 186 TG patients lost their grafts with a median survival of 14 [95% confidence interval (CI) 10-22] months after diagnosis. Proteinuria ≥1 g/24 h at the time of biopsy was detected in 87 patients (46.8%) and the median of proteinuria was 0.89 (range 0.05-6.90) g/24 h. TG patients with proteinuria ≥1 g/24 h had worse 5-year graft survival (29.9% vs. 53.5%, P = 0.001) compared with proteinuria <1 g/24 h. Proteinuria was associated with graft loss in univariable Cox regression [hazard ratio (HR) 1.25, 95% CI, 1.11-1.41, P < 0.001], and in multivariable analysis (adjusted HR 1.26, 95% CI 1.11-1.42, P < 0.001) independent of other risk factors including creatinine at biopsy, positive C4d, history of rejection, and Banff lesion score mesangial matrix expansion. In this cohort of TG patients, proteinuria at indication biopsy is ...Continue Reading

References

May 1, 1985·Kidney International·R K MaryniakM A Weiss
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jeffrey S ZaltzmanRamesh Prasad
Dec 13, 2005·Transplantation·Giovanni BanfiClaudio Ponticelli
Jun 15, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B SisP F Halloran
Jul 5, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M GloorF G Cosio
Oct 11, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D WavamunnoB J Nankivell
Oct 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H AmerF G Cosio
Apr 25, 2009·Annals of Clinical Biochemistry·Edmund J LambPaul E Stevens
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Niamh KieranJolanta Kowalewska
Oct 13, 2009·Journal of the American Society of Nephrology : JASN·Hatem Amer, Fernando G Cosio
Oct 23, 2009·Kidney International·Bertram L KasiskeEthan M Balk
Sep 15, 2010·Transplantation·Rohan JohnAndrew M Herzenberg
May 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio Ponticelli, Giorgio Graziani
Feb 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H AmerF G Cosio
Apr 3, 2013·Nature Reviews. Nephrology·Christophe Legendre, Dany Anglicheau
Jan 1, 2014·Clinical Transplantation·Marcel G NaikUNKNOWN German Sirolimus Study Group
Jul 15, 2015·Journal of the American Society of Nephrology : JASN·Maarten NaesensDirk R J Kuypers
Sep 4, 2015·Transplantation·Anne Tsampalieros, Greg A Knoll
Nov 30, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Georg Heinze, Daniela Dunkler
Oct 14, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Edward J FilipponeJohn L Farber
Jul 22, 2018·Transplantation·Candice RoufosseJan U Becker
Mar 16, 2019·Journal of the American Society of Nephrology : JASN·Olivier AubertAlexandre Loupy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
M Khaled Shamseddin, Greg A Knoll
Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
Ahmed F HamdyMohamed A Ghoneim
Transplant International : Official Journal of the European Society for Organ Transplantation
Claudio Ponticelli, Giorgio Graziani
© 2021 Meta ULC. All rights reserved