The relationship between proton pump inhibitors and renal disease

Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Carine Franco MorschelJosé Carlos Carraro Eduardo

Abstract

Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze recent studies on the matter and discuss the possible consequences of the long-term use of PPIs on renal function.

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May 17, 2019·International Journal of Clinical Pharmacy·Iwyson Henrique Fernandes da CostaMarjorie Moreira Guedes
Nov 24, 2020·Semergen·G M Saiz LaderaJ N García Pascual

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