The relationship between quality of life, cognition, and thyroid status in Graves' disease

Endocrine
Cínthia Minatel RiguettoDenise Engelbrecht Zantut-Wittmann

Abstract

To assess quality of life (QoL) and cognitive function among Graves' disease (GD) patients with different thyroid status, with and without ophthalmopathy. This is a cross-sectional clinic-based study involving 154 patients with GD (81.27% were female, mean age 45.6 ± SD 11.2 years) and 54 (35.06%) had ophthalmopathy. Data were collected after an informed consent from all patients was obtained. All patients completed the 36-Item Short Form Health Survey and Mini-Mental State Examination. Patients with ophthalmopathy also completed the Graves' Orbitopathy Quality of Life Questionnaire. Patients with hyperthyroidism presented a greater impairment in QoL when compared to euthyroidism group. A lower score in physical role functioning was found in both subgroups with active disease (hyperthyroidism and euthyroidism using thionamides). A lower score was also seen in visual function, only in patients with hyperthyroidism, without difference in appearance. No difference was found in cognition between patients. Younger ages at diagnosis, male sex, euthyroidism and absence of ophthalmopathy were factors associated with better QoL, as well as a shorter disease duration was associated with better recall, attention and calculation. An impair...Continue Reading

References

Feb 12, 1998·Thyroid : Official Journal of the American Thyroid Association·M N GerdingW M Wiersinga
Jun 1, 2002·European Journal of Endocrinology·Caroline TerweeWilmar Wiersinga
Nov 13, 2004·European Journal of Endocrinology·T V ElberlingG Waldemar
Sep 27, 2005·Clinical Endocrinology·G J KahalyU T Egle
Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·Mirna Abraham-NordlingGöran Wallin
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·M F SchreckenbergerG J Kahaly
Nov 14, 2006·Psychoneuroendocrinology·Asmus VogelGunhild Waldemar
Aug 5, 2008·Journal of Neuroendocrinology·M BauerP C Whybrow
Jun 3, 2010·BMC Public Health·Isabela M BenseñorMárcia Scazufca
Aug 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Earn H Gan, Simon H S Pearce
Sep 11, 2012·Nigerian Journal of Clinical Practice·C ChattopadhyayS Ghosh
Sep 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Bu B YeapOsvaldo P Almeida
Nov 28, 2012·The Journal of Clinical Endocrinology and Metabolism·Katharina A PontoGeorge J Kahaly
Jun 1, 2013·Clinical Endocrinology·Mads Lillevang-JohansenThomas Heiberg Brix
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Mary H SamuelsKathryn G Schuff
Dec 17, 2015·JAMA : the Journal of the American Medical Association·Henry B Burch, David S Cooper
Jul 3, 2016·Thyroid : Official Journal of the American Thyroid Association·Per CramonÅse Krogh Rasmussen
Aug 4, 2016·Thyroid : Official Journal of the American Thyroid Association·Mary H SamuelsDouglas Bauer
Nov 1, 2016·The New England Journal of Medicine·Terry J Smith, Laszlo Hegedüs
Feb 23, 2017·Archives of Endocrinology and Metabolism·Laura Carolina DelfinoAlicia Teresa Gauna
Nov 1, 2017·Thyroid : Official Journal of the American Thyroid Association·Charlotte Ferløv-SchwensenLaszlo Hegedüs
Apr 11, 2018·Clinical Endocrinology·Helen M ConaglenMarianne S Elston

❮ Previous
Next ❯

Citations

Jul 28, 2020·Indian Journal of Ophthalmology·Bipasha Mukherjee
Jan 2, 2020·Journal of Patient-reported Outcomes·Mingkwan LumyongsatienKrit Pongpirul
Nov 1, 2020·Clinical Endocrinology·Laura Claire LaneTim Cheetham
Sep 23, 2021·Scientific Reports·Nadia Sawicka-GutajMarek Ruchała
Oct 20, 2021·Thyroid : Official Journal of the American Thyroid Association·Alexander H GunnHadiza S Kazaure

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nederlands tijdschrift voor geneeskunde
R J de Keizer
Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society
Francesco CoralloSilvia Marino
Asian Cardiovascular & Thoracic Annals
Anas AboudJan F Gummert
Transactions of the American Ophthalmological Society
R Patrick Yeatts
© 2022 Meta ULC. All rights reserved