The relationship between regional cerebral blood flow and the Wisconsin Card Sorting Test in negative schizophrenia

Psychiatry and Clinical Neurosciences
Zhening LiuJingping Zhao

Abstract

The purpose of this study was to explore the relationship between regional cerebral blood flow (rCBF) and problem-solving thinking in negative schizophrenia. Twenty-one negative schizophrenic patients and 12 normal controls were studied with single photon emission computed tomography (SPECT). Measures of regional cerebral blood flow (rCBF) were taken both at rest and during a prefrontal activation task using Wisconsin Card Sorting Test (WCST). Compared with controls, poor performances on the WCST of total trials category (TT), perseverative errors (PE) and non-perseverative errors (NE) were found in negative schizophrenic (P < 0.05). During WCST activation, patients showed interhemispheric differences in the prefrontal region, but under rest conditions, no such differences manifested. The negative schizophrenia group had a significantly lower rCBF change rate in profrontal lobe during stimulant WCST than those in normal controls (P < 0.05). The negative schizophrenic patient has executive function deficits and lower rCBF perfusion in left profrontal lobes, which suggest that the negative schizophrenic patient has dysfunction of the left profrontal region.

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Citations

Dec 17, 2008·Neurotoxicity Research·José Manuel Rodríguez-SánchezJosé Luis Vázquez-Barquero
Oct 8, 2004·Schizophrenia Research·Maria SemkovskaEmmanuel Stip
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Apr 25, 2007·Cognitive Neuropsychiatry·Anna AbrahamOnur Güntürkün
Mar 11, 2011·Cognitive Neuropsychiatry·Vidyulata KamathMichael T Compton
Aug 25, 2010·Journal of Psychiatry & Neuroscience : JPN·Andreas WilmsmeierAnya Pedersen
Jan 20, 2012·Journal of Neuropsychology·Laura LuntAnthony S David
Apr 2, 2008·Biological Psychiatry·Erin A HeereyJames M Gold
Apr 4, 2009·Seminars in Nuclear Medicine·David K Leung, Ronald L Van Heertum
Dec 13, 2006·International Journal of Psychiatry in Medicine·Jingping ZhaoDesen Yang
Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·M Urban-KowalczykD Strzelecki

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