The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children

Current Opinion in Allergy and Clinical Immunology
Mark L Everard

Abstract

The relationship between respiratory syncytial virus lower-respiratory-tract infections in early childhood and asthma has been the subject of much debate. Most, but not all, previous cohort studies have failed to identify a link between early respiratory syncytial virus infection and atopic asthma. Recent studies have helped clarify some apparently contradictory findings. Cohort studies focusing on wheezing in early childhood have indicated that this is associated with an increased incidence of atopic asthma but that this risk is not increased by respiratory syncytial virus infection. Indeed, wheeze associated with rhinovirus infection may be a better marker for possible asthma. In contrast, there is no increased risk of atopic disease in infants with respiratory syncytial virus 'acute bronchiolitis', a phenotype characterized by widespread crepitation. Post-bronchiolitic symptoms are associated with intercurrent viral infections in particular and the incidence of symptoms falls rapidly during infancy. These studies confirm earlier suggestions that the phenotype of respiratory illness and hence the host response rather than the infecting organism is the best predictor of the future pattern of respiratory illness. Such considera...Continue Reading

References

Feb 19, 1976·The New England Journal of Medicine·C B HallG R Douglas
Apr 1, 1992·Archives of Disease in Childhood·M MurrayA D Milner
Apr 1, 1991·The Journal of Infectious Diseases·C B HallK C Schnabel
May 1, 1987·Pediatric Pulmonology·K H CarlsenJ Leegaard
Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Nov 1, 1985·Archives of Disease in Childhood·M S WebbA S Swarbrick
Nov 1, 1971·The Journal of Pediatrics·J C Rooney, H E Williams
Jun 27, 1981·British Medical Journal·D G SimsJ F Soothill
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Nov 1, 1994·Archives of Disease in Childhood·M L EverardA D Milner
Dec 18, 1993·Lancet·D M Fleming, K W Cross
Oct 1, 1994·The Journal of Infectious Diseases·S GilchristL J Anderson
Jan 1, 1994·The Journal of Experimental Medicine·W H AlwanP J Openshaw
Apr 1, 1997·Archives of Disease in Childhood·V NobleA D Milner
Apr 1, 1997·Acta Paediatrica·G WennergrenS Redfors
Nov 20, 1998·Allergy·S L Johnston
Sep 18, 1999·The European Respiratory Journal·M Abu-HarbM L Everard
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Dec 6, 2000·The European Respiratory Journal·H E ElphickM L Everard
May 1, 2001·Journal of Paediatrics and Child Health·P K SmithK D Forsyth
May 10, 2002·Pediatric Pulmonology·Kevin J MobbsC Anthony Hart
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Hans Bisgaard, UNKNOWN Study Group on Montelukast and Respiratory Syncytial Virus
Nov 27, 2002·The European Respiratory Journal·U SchauerV Stephan
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Julian P LeggJohn O Warner
Jan 1, 1959·Clinical Proceedings - Children's Hospital of the District of Columbia·W R O'REILLY
Dec 1, 1963·The Journal of Pediatrics·E O REYNOLDS, C D COOK
Jan 30, 2004·The New England Journal of Medicine·John V WilliamsJames E Crowe
Jun 24, 2004·Pediatric Pulmonology·M KorppiS Remes
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Nov 3, 2004·Archives of Pediatrics & Adolescent Medicine·Eija Piippo-SavolainenMatti Korppi
Nov 9, 2004·Paediatric Respiratory Reviews·Jayesh M Bhatt, Mark L Everard
Nov 17, 2004·The Pediatric Infectious Disease Journal·Matti KorppiTiina M Reijonen
Apr 29, 2005·The New England Journal of Medicine·Ann R FalseyEdward E Walsh

❮ Previous
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Citations

Nov 7, 2007·Clinical Reviews in Allergy & Immunology·Robert C Welliver
Mar 5, 2009·The Pediatric Infectious Disease Journal·Tuomas JarttiOlli Ruuskanen
Mar 20, 2009·The Pediatric Infectious Disease Journal·Mark EverardKaren Plant
Oct 12, 2007·Journal of Virology·Peter L Collins, Barney S Graham
Feb 29, 2008·Annual Review of Immunology·Benjamin D MedoffAndrew D Luster
Mar 17, 2009·American Journal of Respiratory and Critical Care Medicine·Simon Francis ThomsenHans Bisgaard
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Claudia E KuehniMichael Silverman
May 6, 2010·American Journal of Respiratory and Critical Care Medicine·Junyan HanErwin W Gelfand
Feb 14, 2014·American Journal of Respiratory Cell and Molecular Biology·Junyan HanErwin W Gelfand
Dec 23, 2014·Current Medical Research and Opinion·LeRoy M Graham, Nemr Eid
May 15, 2012·Pulmonary Pharmacology & Therapeutics·Matthew E Poynter
Feb 1, 2008·Pharmacology & Therapeutics·Nicole G HansbroPhilip M Hansbro
Apr 10, 2007·The Journal of Allergy and Clinical Immunology·Pascal ChanezIsabelle Vachier
Jun 20, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Kummeling, C Thijs
Jan 10, 2009·Allergy·K N PriftisG P Chrousos
Jun 27, 2006·Paediatric Respiratory Reviews·Mark L Everard
Jun 19, 2013·Environment International·Ki-Hyun KimEhsanul Kabir
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Matthew SchallerSteven L Kunkel
Oct 20, 2018·Minerva pediatrica·Virginia MirraRenato Cutrera
Jul 13, 2011·Journal of Allergy·Renée C BensonClaudia R Morris
Mar 1, 2015·European Journal of International Relations·Linus Hagström
Apr 29, 2019·Ambio·Vanessa S DagaJean R S Vitule
Feb 23, 2013·Epidemiology·Guang-Hui DongEdwin Trevathan
Jul 25, 2014·Experimental Biology and Medicine·Sung-Ho KimXue-Jiao Qian
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mieke BevelanderMatthew E Poynter
Aug 28, 2021·The Pediatric Infectious Disease Journal·W Abdullah BrooksMaria Deloria Knoll

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