The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex.

Journal of Psychiatric Research
Ananda B AmstadterC W Lejuez

Abstract

Although adolescents frequently engage in a variety of risky behaviors, much remains unknown about the specific etiologies of such tendencies. Candidate genetic variants, such as the COMT Val(158)Met polymorphism, may be related to risk-taking propensity, particularly as this variant is linked to functional enzymatic differences influencing dopamine function in regions including the prefrontal cortex. The present study aimed to examine the COMT Val(158)Met variant in relation to risk-taking propensity in a community sample of youth. As part of a larger longitudinal study on adolescent risk behaviors, 223 youths (average age 11.3 years) from the metropolitan Washington D.C. area completed a measure of risk-taking propensity, the Balloon Analog Risk Task-Youth Version (BART-Y), and provided saliva samples for DNA extraction and genotyping. Results indicate that females, but not males, who are carriers of the COMT 158Met allele had higher risk-taking propensity scores on the BART-Y compared to Val homozygotes. Analyses were also conducted in the 111 European American participants, and results were consistent with those of the full sample analyses. This study represents the first investigation of a genetic substrate of risk-taking ...Continue Reading

References

Jul 1, 1995·The International Journal of the Addictions·K H BeckK M Fingar
Jul 25, 1997·American Journal of Medical Genetics·D J VandenberghH M Lachman
Jul 1, 1997·Behavioral Medicine·H S ResnickD G Kilpatrick
Feb 15, 2001·Drug and Alcohol Dependence·D R MilesR W Pickens
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Mar 11, 2004·The International Journal of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
Jun 19, 2004·Journal of Psychiatric Research·Jong-Min WooBum-Hee Yu
Sep 1, 2004·The American Journal of Psychiatry·Monica McGrathImmaculata De Vivo
Jun 3, 2005·The American Journal of Psychiatry·Matt McGue, William G Iacono
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sarah K WahlBrian R Flay
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Mary-Anne EnochDavid Goldman
Aug 30, 2006·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Jeffrey R MeaselleDavid W Springer
Dec 6, 2006·Archives of General Psychiatry·Emily M DrabantDaniel R Weinberger
Feb 6, 2007·Nature Neuroscience·Susheel VijayraghavanAmy F T Arnsten
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Undine E LangJuergen Gallinat
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J Harrison, Elizabeth M Tunbridge
Dec 18, 2007·Social Psychiatry and Psychiatric Epidemiology·Rani A Desai, Marc N Potenza
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stella G GiakoumakiPanos Bitsios
Jul 22, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Steven P SchinkeKristin C A Cole
Aug 6, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Andrey P AnokhinAndrew C Heath
Aug 26, 2009·Journal of Child and Adolescent Psychopharmacology·Christian E WaughIan H Gotlib
Mar 24, 2010·Prevention Science : the Official Journal of the Society for Prevention Research·Laura MacPhersonC W Lejuez
May 25, 2010·Alcoholism, Clinical and Experimental Research·Laura MacPhersonC W Lejuez
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chunhui ChenJared Lessard
Apr 26, 2011·Biological Psychiatry·Iroise DumontheilTorkel Klingberg
Jul 13, 2011·Biological Psychiatry·Ahmad R Hariri

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Citations

Jun 29, 2013·AIDS·Erin E SundermannPauline M Maki
Aug 21, 2012·Genes, Brain, and Behavior·T M LancasterE A Heerey
Mar 30, 2013·Journal of Psychiatric Research·Ximena GoldbergLourdes Fañanás
Feb 28, 2015·BioMed Research International·Marta de Castro-CatalaAraceli Rosa
Jul 16, 2014·Neuroscience and Biobehavioral Reviews·David M LydonCharles F Geier
Mar 19, 2014·Frontiers in Behavioral Neuroscience·Sean C Godar, Marco Bortolato
Dec 18, 2014·Journal of Neurovirology·Erin E SundermannPauline M Maki
Aug 1, 2015·Journal of Psychiatric Research·Stephanie M GorkaStewart A Shankman

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