The Relationship Between Sensory Loss and Persistent Pain 1 Year After Breast Cancer Surgery

The Journal of Pain : Official Journal of the American Pain Society
Kenneth Geving AndersenEske Kvanner Aasvang

Abstract

Moderate to severe persistent pain after breast cancer surgery (PPBCS) affects 10 to 20% of the patients. Sensory dysfunction is often concomitantly present suggesting a neuropathic pain state. The relationship between various postoperative pain states and sensory dysfunction has been examined using quantitative sensory testing (QST), but only 2 smaller studies have examined PPBCS and sensory dysfunction in the surgical area. The purpose of this prospective study was to assess the relative importance of sensory function and PPBCS. QST consisted of sensory mapping, tactile detection threshold, mechanical pain threshold, and thermal thresholds. Two hundred ninety patients were enrolled and results showed that 38 (13%) had moderate to severe pain and 246 (85%) had hypoesthesia in the surgical area 1 year after surgery. Increased hypoesthesia areas were associated with pain at rest as well as during movement (P = .0001). Pain during movement was associated with a side-to-side difference of 140% (P = .001) for tactile detection threshold and 40% (P = .01) for mechanical pain threshold as well as increased thermal thresholds in the axilla (P > .001). Logistic regression models controlling for confounders showed larger areas of hypoes...Continue Reading

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Citations

May 1, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S La CesaM Framarino-Dei-Malatesta
Jul 20, 2019·Journal of Midwifery & Women's Health·Dawn L LovelaceDwynn Golden
May 28, 2020·Breast Cancer Research and Treatment·L MustonenH Harno
Jul 31, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Shuai ZhaoYuan Zhang
Jul 23, 2020·Scandinavian Journal of Pain·Laura MustonenEija Kalso
Jan 8, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Bruna Baungarten Hugen BackFabiana Flores Sperandio
Dec 16, 2021·Acta Anaesthesiologica Scandinavica·Ulrik H U HolmMartin Vedel Nielsen

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