The relationship between serum levels of vascular calcification inhibitors and carotid plaque vulnerability

Journal of Vascular Surgery
N P E KadoglouC D Liapis

Abstract

Osteopontin (OPN) and osteoprotegerin (OPG) are well-known vascular calcification inhibitors, which have been recently demonstrated to correlate with inflammation and cardiovascular events incidence. The aim of this cross-sectional study is to survey whether OPN and OPG are involved in carotid plaque vulnerability. For this reason, we assessed serum OPN and OPG levels in patients with carotid stenosis, and we explored their relationship with carotid plaque echogenicity and subsequent cerebrovascular ischemic events. A total of 164 Whites were selected from a large cohort of 297 subjects to participate. In particular, 114 patients (61 men, 53 women), aged 55 to 80, had recently-diagnosed ICA stenosis higher than 50%. A group of 50 age-, sex-, and body mass index (BMI)-matched healthy individuals served as healthy controls. Patients with renal failure, hypothyroidism, osteoporosis, and lipid-lowering therapy were excluded. Images of both carotids were obtained from all participants using a high-resolution color duplex ultrasound and the gray-scale median (GSM) score was calculated. Brain computed tomography (CT), and magnetic resonance imaging (MRI) scans when CT was questionable, were performed on all patients with carotid steno...Continue Reading

References

Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·C D LiapisA G Kostakis
May 25, 2002·Heart and Vessels·Satoru ChibaAkira Kitabatake
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Mario De MichelePaolo Rubba
May 15, 2004·Stroke; a Journal of Cerebral Circulation·Jonathan GolledgeMirko Karan
Aug 7, 2004·Journal of Vascular Surgery·Wael E ShaalanHisham S Bassiouny
Mar 29, 2005·Angiology·Nikolaos P KadoglouChristos D Liapis
Sep 21, 2005·Journal of Vascular Surgery·Jennifer K GroganHisham S Bassiouny
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Norbert NighoghossianPhilippe Douek
Apr 20, 2006·Atherosclerosis·Anders VikJohn-Bjarne Hansen
May 10, 2006·Journal of the American College of Cardiology·Dhakshinamurthy Vijay AnandRoger Corder
Jun 17, 2006·Clinical Science·Mie KurataJitsuo Higaki
Nov 11, 2006·Circulation Research·Rebecca C JohnsonJoseph Loscalzo
Dec 13, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S K KakkosD Thomas
Mar 6, 2007·Biochemical and Biophysical Research Communications·Jing-Jing LiAi-Ying Li
Mar 21, 2007·Obesity·Andy MenkeJiang He

❮ Previous
Next ❯

Citations

Sep 29, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Constantinos GiaginisStamatios Theocharis
Aug 13, 2010·Biomarkers in Medicine·Nikolaos P E KadoglouChristos D Liapis
Oct 4, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tae-Jin SongJi Hoe Heo
Apr 18, 2012·Scandinavian Cardiovascular Journal : SCJ·Susanne Elisabeth HosbondHans Mickley
Feb 5, 2016·Lipids in Health and Disease·Anna Gluba-BrzózkaJacek Rysz
Jan 21, 2012·Ultrasound in Medicine & Biology·Hoda NassarKazuo Kitagawa
Jul 16, 2010·Atherosclerosis·Linda HermusClark J Zeebregts
Nov 15, 2008·Atherosclerosis·Ann Van Campenhout, Jonathan Golledge
Oct 24, 2015·Ultrasound in Medicine & Biology·Simeon LechareasDespoina Perrea
Jul 13, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Efthimios D AvgerinosChristos D Liapis
Dec 18, 2009·Journal of Cellular and Molecular Medicine·Yvonne NitschkeFrank Rutsch
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Pinar DemirAydin Turkmen
Aug 19, 2014·The British Journal of Surgery·P W StatherM J Bown
Oct 20, 2009·Journal of Vascular Surgery·Nikolaos P E KadoglouChristos D Liapis
Dec 17, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N P E KadoglouC D Liapis
Apr 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N P E KadoglouC D Liapis
Sep 18, 2012·Regulatory Peptides·Nikolaos P E KadoglouChristos D Liapis
Mar 19, 2014·European Journal of Radiology·Shigeki YamadaHidenori Miyake
Aug 15, 2012·Nature Reviews. Rheumatology·Christos E LampropoulosDavid P D'Cruz
Aug 27, 2011·Wiener medizinische Wochenschrift·Daniela-Eugenia MalligaAstrid Fahrleitner-Pammer
Jul 1, 2016·Coronary Artery Disease·Rui XuYasinjan Maimti
Jun 24, 2017·Clinical Kidney Journal·Anders VikJohn-Bjarne Hansen
Jul 14, 2020·Journal of Cellular and Molecular Medicine·Yunxiang ZhouAnwen Shao
Mar 18, 2017·Chinese Medical Journal·Xiang-Dong XiongGui-Hai Chen
Apr 14, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·De-Hua SongChun Song
Jan 11, 2018·International Journal of Cardiology·Federico CarboneFabrizio Montecucco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.