The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children

Clinical Laboratory
Ramazan GidenHamza Karabag

Abstract

Oxidative stress may induce brain injury. Thiols are one of the most important antioxidant agents, and thiol/disulphide (SH/SS) homeo stasis is a novel oxidative stress marker. The goal of the study was to investigate the relationship of thiol levels and SH/SS homeostasis with head trauma in pediatric patients. This prospective study was conducted in 85 consecutive pediatric patients aged < 18 years with isolated head trauma and 58 age- and gender-matched healthy controls in the Emergency Department (ED). The mean age was 4.40 ± 3.03 years for the patient group and 4.75 ± 1.81 years for the controls (p > 0.05). There were no significant differences in biochemical parameters including serum albumin, urea, alanine aminotransferase, total bilirubin, uric acid, high-sensitivity C-reactive protein (hs-CRP), and white blood cells (WBC) in the patient and control groups (for each, p > 0.05). The thiol (SH) level was significantly higher in the patient group than in the controls (388.83 ± 51.949 vs. 369.04 ± 37.62 μmol/L; p = 0.009). The total thiol (TT) level was somewhat higher in the patient group, but the difference was not significant (416.11 ± 47.29 vs. 405.08 ± 35.27 μmol/L; p = 0.113). The disulphide (SS) level was lower in the...Continue Reading

Citations

Aug 11, 2021·International Journal of Clinical Practice·Can İhsan ÖztorunEmrah Şenel

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brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.