The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort

Atherosclerosis
Tomonori OkamuraNIPPON DATA80 Research Group

Abstract

No study has shown a positive relationship between hypercholesterolemia and all-cause mortality in the Japanese population. Therefore, a cohort study of 17.3 years' duration was conducted on 9216 participants aged 30 years or older, selected randomly from throughout Japan. In both the lowest (<4.14mmol/L, 160mg/dl) and highest (>or=6.71mmol/L, 260mg/dl) total cholesterol (TC) groups, there was a positive association between TC and risk of all-cause mortality (hazard ratio (HR) 1.19; 95% confidence interval (CI), 1.03-1.37 and 1.36 (95% CI, 1.05-1.77), respectively). The lowest TC group had an increased risk of liver disease (HR 3.03; 95% CI, 1.70-5.43), whereas the highest TC group had an increased risk of coronary heart disease (HR 3.81; 95% CI, 1.70-5.43). After exclusion of deaths due to liver disease during the entire follow-up period and all-cause deaths within the first 5 years of follow-up, the increased HR in the lowest TC group disappeared (HR 1.05; 95% CI, 0.89-1.24). Although the cut-off point seemed to be higher than that for Western populations, hypercholesterolemia was shown to be positively associated with all-cause mortality in Japan.

References

Jan 1, 1992·JAMA : the Journal of the American Medical Association·G D SmithG Rose
Apr 3, 1996·JAMA : the Journal of the American Medical Association·E L MurphyG J Nemo
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F DuboisA Goudeau
Oct 18, 2000·International Journal of Epidemiology·I SaitoT Yamashita
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·Y TanizakiM Fujishima
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Jan 25, 2003·Journal of Internal Medicine·T OkamuraUNKNOWN Nippon Data80 Research Group
May 29, 2004·Stroke; a Journal of Cerebral Circulation·Hirotsugu UeshimaOsamu Iimura
Jun 17, 2004·American Heart Journal·Tomonori OkamuraUNKNOWN NIPPONDATA80 Research Group
Dec 23, 2004·Journal of Clinical Epidemiology·Tomonori OkamuraUNKNOWN NIPPON DATA80 research group

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Citations

Aug 2, 2011·Cardiovascular Drugs and Therapy·Ryo YoshimotoTatsuya Sawamura
Jun 11, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michiko EndoMasahiko Kurabayashi
Dec 19, 2008·Journal of Human Hypertension·A HozawaUNKNOWN NIPPON DATA80 Research Group
Jul 11, 2012·Current Opinion in Lipidology·Tatsuya SawamuraYoshiko Fujita
Dec 12, 2012·Annals of Nutrition & Metabolism·Tomohito HamazakiRokuro Hama
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Takako YamamotoUNKNOWN NIPPON DATA80 Research Group
Oct 5, 2010·Nihon eiseigaku zasshi. Japanese journal of hygiene·Hidekuni Inadera, Tomohito Hamazaki
Oct 14, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tamio Teramoto
Jul 31, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoKoutaro Yokote
Jul 31, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoKoutaro Yokote
Dec 17, 2008·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoMasayuki Yokode
Feb 25, 2014·Journal of Atherosclerosis and Thrombosis·Nobutaka Inoue
Mar 13, 2014·Clinical Interventions in Aging·Yutaka TakataKazuo Sonoki
Sep 12, 2007·International Journal of Epidemiology·Atsushi HozawaUNKNOWN Hirotsugu Ueshima for NIPPON DATA80 Research group
Oct 20, 2012·Journal of Hypertension·Naoyuki TakashimaUNKNOWN NIPPON DATA80 Research Group
Oct 9, 2009·Clinical and Experimental Hypertension : CHE·Yuko OhtaMichio Ueno
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michal Schnaider Beeri, Uri Goldbourt
Aug 1, 2015·Journal of Atherosclerosis and Thrombosis·Atsushi Hozawa, Tomonori Okamura
Jan 23, 2009·International Journal of Cardiology·Longjian LiuHirotsugu Ueshima
Sep 5, 2014·Journal of Atherosclerosis and Thrombosis·Daisuke SugiyamaHirotsugu Ueshima
Jul 6, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoru YatsujiKeiko Shiratori
Apr 19, 2008·Obesity·Atsushi HozawaUNKNOWN NIPPON DATA80 Study Group
Jun 23, 2009·International Journal of Cancer. Journal International Du Cancer·Hiroyasu IsoUNKNOWN JPHC Study Group
Sep 3, 2013·Psychiatry and Clinical Neurosciences·Yutaro SuzukiToshiyuki Someya

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