The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women

Disease Models & Mechanisms
Jocelyn M WesselsCharu Kaushic

Abstract

The role of sex hormones in regulating immune responses in the female genital tract has been recognized for decades. More recently, it has become increasingly clear that sex hormones regulate susceptibility to sexually transmitted infections through direct and indirect mechanisms involving inflammation and immune responses. The reproductive cycle can influence simian/human immunodeficiency virus (SHIV) infections in primates and HIV-1 infection in ex vivo cervical tissues from women. Exogenous hormones, such as those found in hormonal contraceptives, have come under intense scrutiny because of the increased susceptibility to sexually transmitted infections seen in women using medroxyprogesterone acetate, a synthetic progestin-based contraceptive. Recent meta-analyses concluded that medroxyprogesterone acetate enhanced HIV-1 susceptibility in women by 40%. In contrast, estradiol-containing hormonal contraceptives were not associated with increased susceptibility and some studies reported a protective effect of estrogen on HIV/SIV infection, although the underlying mechanisms remain incompletely understood. Recent studies describe a key role for the vaginal microbiota in determining susceptibility to sexually transmitted infectio...Continue Reading

References

Jun 1, 1986·The Journal of Infectious Diseases·D A EschenbachM G Gravett
Dec 1, 1970·Endocrinology·A T Gregoire, D W Richardson
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G B HillL T Gutman
Mar 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·B R MøllerS C Mogensen
Apr 1, 1997·Biology of Reproduction·I K GipsonJ A Hill
May 1, 1997·Clinical and Diagnostic Laboratory Immunology·C Tevi-BénissanG Grésenguet
Feb 7, 1998·AIDS Research and Human Retroviruses·M PeetersE Delaporte
Oct 9, 1999·The Journal of Infectious Diseases·J R SchwebkeH L Weiss2
Jun 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A EschenbachW E Stamm
Jun 1, 2001·Fertility and Sterility·F WieserJ C Huber
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raina N FichorovaRobin R Ingalls
May 10, 2002·The Journal of Infectious Diseases·Jeanne M MarrazzoSharon L Hillier
Jun 6, 2002·Microbes and Infection·Michael W Russell, Jiri Mestecky
Feb 21, 2003·Microbes and Infection·Christopher J Miller, Robin J Shattock
Jun 12, 2003·Current Topics in Microbiology and Immunology·T B H Geijtenbeek, Y van Kooyk
Jul 2, 2003·Nature Medicine·Melissa Pope, Ashley T Haase
Mar 1, 1964·American Journal of Obstetrics and Gynecology·D E STEWART-TULL
Sep 2, 2004·Obstetrics and Gynecology·Sharry VeresBart Burington
Mar 31, 2005·Molecular and Cellular Biology·Serena GhislettiElisabetta Vegeto
Oct 7, 2005·Archives of Gynecology and Obstetrics·Miranda Farage, Howard Maibach
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Todd M SchaeferCharles R Wira
Mar 16, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura M EnomotoAdriana Weinberg
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Aug 22, 2007·The Journal of Nutrition·Yasmin H NeggersMark A Klebanoff
Jan 19, 2008·American Journal of Reproductive Immunology : AJRI·Melissa M Herbst-KralovetzRichard B Pyles
Feb 26, 2008·American Journal of Obstetrics and Gynecology·Rebecca M BrotmanJonathan M Zenilman
May 13, 2008·Nature Reviews. Immunology·Florian Hladik, M Juliana McElrath
Jan 1, 1993·Infectious Diseases in Obstetrics and Gynecology·P D GinkelH P Dalton

❮ Previous
Next ❯

Citations

Jan 12, 2020·American Journal of Reproductive Immunology : AJRI·Jieying XuYanzhi Du
Sep 21, 2019·Microbiology Resource Announcements·Maximilien ClabautMarc G J Feuilloley
Apr 2, 2020·Frontiers in Immunology·Salwan Al-NasiryBoris W Kramer
Feb 13, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Tingting HuWenChieh Chen
Mar 9, 2021·Anais Da Academia Brasileira De Ciências·Marcelle O AlmeidaRodrigo D O Carvalho
Mar 11, 2021·Periodontology 2000·A M Marije KaanEgija Zaura
Jun 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Negin AlizadehmohajerAdele Balouchi
Mar 16, 2021·Current HIV/AIDS Reports·Marta Rodriguez-GarciaMimi Ghosh
Feb 13, 2021·Tissue Engineering. Part C, Methods·Ingrid SabaStéphane Bolduc
Oct 27, 2020·Current Opinion in Physiology·Laura Moreno de LaraMarta Rodriguez-Garcia
Apr 17, 2021·Phytotherapy Research : PTR·Haiyue ZhaoLan Shen
Apr 18, 2021·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Mar 20, 2021·Menopause : the Journal of the North American Menopause Society·James K Pru
May 16, 2021·American Journal of Reproductive Immunology : AJRI·Hossaena AyeleAdam Burgener
Feb 13, 2021·The Journal of Infectious Diseases·Susan TuddenhamJeanne M Marrazzo
Jun 25, 2021·The Journal of Clinical Investigation·Rena D AstronomoM Juliana McElrath
Jan 1, 2022·AIDS Research and Human Retroviruses·Scott Sherrill-MixMimi Ghosh

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception
PCR
hormone replacement therapy
flow cytometry
biopsies
lavage

Related Concepts

Related Feeds

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.