Abstract
To determine how well skin symptoms considered specific to SSc are captured by patient reported outcomes currently used for assessing patients with SSc, the SHAQ, or skin disease, the Skindex-29; and how well these symptoms correlate with the extent of skin disease on physical exam and skin pathology. SSc patients completed the scleroderma modification of the Health Assessment Questionnaire (SHAQ), Skindex-29 and a Skin Symptom Assessment questionnaire developed for this study. Correlations were assessed between the Skin Symptom Assessment and SHAQ, Skindex-29, modified Rodnan skin score, and skin pathological features including myofibroblast staining completed on the same date. Tight, hard and rigid/stiff skin symptoms correlated moderately highly with the modified Rodnan skin score (r = 0.445, P = 0.0008; r = 0.486, P = 0.0002; and r = 0.488, P = 0.0002, respectively). Tight skin symptoms correlated moderately with myofibroblast infiltration (r = 0.544, P = 0.0023) and hyalinized collagen (r = 0.442, P = 0.0164), while both hard and rigid/stiff skin correlated moderately with inflammation (r = 0.401, P = 0.0310 and r = 0.513, P = 0.0045), myofibroblast infiltration(r = 0.480, P = 0.0084 and r = 0.527, P = 0.0033) and hyaliniz...Continue Reading
References
May 1, 1980·Arthritis and Rheumatism
Jan 1, 1981·Bulletin on the Rheumatic Diseases
Nov 1, 1994·Medical Care·J N KatzM H Liang
Nov 1, 1996·The Journal of Investigative Dermatology·M M ChrenS J Zyzanski
Nov 19, 1997·Arthritis and Rheumatism·V D Steen, T A Medsger
Nov 26, 1997·Archives of Dermatology·M M ChrenS J Zyzanski
Sep 8, 1998·The Journal of Bone and Joint Surgery. American Volume·J J IrrgangC D Harner
Nov 18, 2000·Arthritis and Rheumatism·P J ClementsD E Furst
Sep 13, 2002·Archives of Dermatology·John De KorteJan D Bos
Nov 26, 2002·Clinical Rheumatology·F SalaffiM Carotti
Jun 23, 2006·The New England Journal of Medicine·Donald P TashkinUNKNOWN Scleroderma Lung Study Research Group
Nov 1, 2006·Arthritis and Rheumatism·Eugene Y KissinRobert Lafyatis
Feb 3, 2007·Arthritis and Rheumatism·François RannouLuc Mouthon
Jan 11, 2012·The British Journal of Dermatology·P Fernandez-PeñasA García-Díez
Jan 31, 2012·Dermatologic Clinics·Mary-Margaret Chren
Jun 20, 2012·The British Journal of Dermatology·R VasquezB F Chong
Aug 28, 2012·Medical Care·Sara AhmedUNKNOWN International Society for Quality of Life Research
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Jacob M van LaarUNKNOWN EBMT/EULAR Scleroderma Study Group
Citations
Oct 4, 2016·Annales de dermatologie et de vénéréologie·J-L Schmutz
Mar 7, 2019·Journal of Digestive Diseases·Hong YangJia Ming Qian
Feb 28, 2020·Experimental and Therapeutic Medicine·Elena RezusCiprian Rezus
Aug 20, 2019·Arthritis Care & Research·Laura RossMandana Nikpour
Nov 30, 2018·Frontiers in Immunology·Arjan van CaamPeter van der Kraan
May 24, 2018·Nature Reviews. Rheumatology·Peter J WermuthSergio A Jimenez
Sep 5, 2018·Frontiers in Immunology·Niloufar KavianFrederic Batteux
Jul 18, 2017·Clinical Reviews in Allergy & Immunology·Caterina FerreliLaura Atzori
Sep 23, 2020·Advances in Rheumatology·Marília de Fátima Cirioli de OliveiraRenata Cristina Campos Pereira Silveira
Oct 23, 2020·Arthritis Care & Research·Ting Yi Jessica Chang, Janet E Pope
Nov 28, 2020·Current Rheumatology Reports·Kimberly Showalter, Jessica K Gordon
Jul 21, 2021·Nature Communications·Tracy TabibRobert Lafyatis