The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis

Rheumatology
Jessica ZiemekRobert Lafyatis

Abstract

To determine how well skin symptoms considered specific to SSc are captured by patient reported outcomes currently used for assessing patients with SSc, the SHAQ, or skin disease, the Skindex-29; and how well these symptoms correlate with the extent of skin disease on physical exam and skin pathology. SSc patients completed the scleroderma modification of the Health Assessment Questionnaire (SHAQ), Skindex-29 and a Skin Symptom Assessment questionnaire developed for this study. Correlations were assessed between the Skin Symptom Assessment and SHAQ, Skindex-29, modified Rodnan skin score, and skin pathological features including myofibroblast staining completed on the same date. Tight, hard and rigid/stiff skin symptoms correlated moderately highly with the modified Rodnan skin score (r = 0.445, P = 0.0008; r = 0.486, P = 0.0002; and r = 0.488, P = 0.0002, respectively). Tight skin symptoms correlated moderately with myofibroblast infiltration (r = 0.544, P = 0.0023) and hyalinized collagen (r = 0.442, P = 0.0164), while both hard and rigid/stiff skin correlated moderately with inflammation (r = 0.401, P = 0.0310 and r = 0.513, P = 0.0045), myofibroblast infiltration(r = 0.480, P = 0.0084 and r = 0.527, P = 0.0033) and hyaliniz...Continue Reading

References

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Citations

Oct 4, 2016·Annales de dermatologie et de vénéréologie·J-L Schmutz
Mar 7, 2019·Journal of Digestive Diseases·Hong YangJia Ming Qian
Aug 20, 2019·Arthritis Care & Research·Laura RossMandana Nikpour
Nov 30, 2018·Frontiers in Immunology·Arjan van CaamPeter van der Kraan
May 24, 2018·Nature Reviews. Rheumatology·Peter J WermuthSergio A Jimenez
Jul 18, 2017·Clinical Reviews in Allergy & Immunology·Caterina FerreliLaura Atzori
Sep 23, 2020·Advances in Rheumatology·Marília de Fátima Cirioli de OliveiraRenata Cristina Campos Pereira Silveira
Oct 23, 2020·Arthritis Care & Research·Ting Yi Jessica Chang, Janet E Pope
Nov 28, 2020·Current Rheumatology Reports·Kimberly Showalter, Jessica K Gordon

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