PMID: 3747142May 1, 1986Paper

The relationship between stomach cancer and intestinal metaplasia of the gastric mucosa and food intake

Gan no rinsho. Japan journal of cancer clinics
H Yamakawa

Abstract

The natural history of intestinal metaplasia of gastric mucosa was studied in 414 rural inhabitants; 213 males and 201 females, from Chokai Village in Akita Prefecture in the northeast part of Japan's main island of Honshu. The subjects were examined by a mobile gastrointestinal unit and were biopsied at eight standard points of the gastric mucosa. The specimens were examined histologically, and were divided into 4 grades. The metaplasia index (MI) was adopted as a quantitative expression of the severity of intestinal metaplasia of the gastric mucosa. The MI of the three areas of the village were compared with the different incidences of stomach cancer. The following results were obtained: in gastric mucosa. The average values of the MI among the male population were highest at the high-risk area, low at the low-risk area and intermediate at the moderate-risk area of gastric cancer. Whereas, the values among females showed no differences in these three areas. The risks for stomach cancer also were almost equal. These phenomena would show a very close relationship between intestinal metaplasia and the incidence of stomach cancer. There was a positive correlation (p less than 0.01) between MI and the detection rates of stomach ca...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.