THE RELATIONSHIP BETWEEN STOPPER POSITION AND INJECTION VOLUME IN RANIBIZUMAB AND AFLIBERCEPT PREFILLED SYRINGES.

Retina
John W Hinkle, Jason Hsu

Abstract

To determine the relationship between stopper position and injection volume in aflibercept and ranibizumab prefilled syringes (PFS). Empty aflibercept 2.0 mg PFS and ranibizumab 0.3 mg and 0.5 mg PFS were collected and refilled with saline. The stopper was positioned relative to the preprinted mark, and resulting injection volumes were recorded. The position for double the on-label volume was confirmed with repeated testing. The quantitative relationship between position and volume was calculated. In ranibizumab PFS, doubling the distance increased the volume injected by 2.6 times. Positioning the stopper 4.0, 3.0, 2.0, and 0 mm proximal to and 1.0 mm distal to the mark injected volumes of 0.13, 0.1, 0.08, 0.05, and 0.03 mL, respectively. The relationship between position (x) and volume (y) was y = 0.019x + 0.048. In aflibercept PFS, doubling the distance increased the volume injected by 3.2 times. Positioning the stopper 2.5, 2.0, 1.0, and 0 mm proximal to and 1.0 mm distal to the mark injected volumes of 0.16, 0.14, 0.11, 0.05, and 0.02 mL, respectively. The relationship between position (x) and volume (y) was y = 0.041x + 0.059. Proper positioning of the stopper at the preprinted mark accurately delivers the on-label volume ...Continue Reading

References

Jan 27, 2005·Investigative Ophthalmology & Visual Science·Ioannis G PallikarisMiltiadis K Tsilimbaris
Jul 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Quan Dong NguyenUNKNOWN Clear-It 1 Investigators
Dec 16, 2018·American Journal of Ophthalmology·Philip P StoreyUNKNOWN Post-Injection Endophthalmitis (PIE) Study Group
May 23, 2019·Clinical Ophthalmology·Thérèse M Sassalos, Yannis M Paulus

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