PMID: 8601043Sep 1, 1995Paper

The relationship between systemic oxygen uptake and delivery during moderate hypothermic cardiopulmonary bypass: critical values and effects of vasodilation by hydralazine

Perfusion
F CavaliereR Schiavello

Abstract

The relationship between oxygen delivery (DO2) and uptake (VO2) has been studied during moderately hypothermic cardiopulmonary bypass (CPB) in 15 patients undergoing myocardial revascularization. As soon as nasopharyngeal temperature was lowered to 32 degrees C, blood flow was decreased from 2.4 to 2.0 l/min/m2. Arterial and mixed venous blood gas analyses were performed five and eight minutes later and DO2 and VO2 were calculated; VO2 stabilized in five minutes after changing blood flow and neither DO2 nor VO2 values changed three minutes later (DO2: 217 +/- 19 versus 215 +/- 17 ml/min/m2; VO2: 63 +/- 12 versus 66 +/- 14 ml/min/m2). Blood flow then was increased to 2.3 l/min/m2 and DO2 and VO2 were determined again, five minutes later; they both increased significantly, to 243 +/- 20 and 74 +/- 13 ml/min/m2, respectively. However, a further blood flow increase to 2.6 l/min/m2 which caused DO2 to increase to 277 +/- 24 ml/min/m2, did not affect VO2 which was unchanged five minutes later (76 +/- 13 ml/min/m2); VO2 dependence on DO2 values higher than 243 +/- 20 ml/min/m2 was consequently ruled out. Ten patients, having a mean arterial pressure higher than 80 mmHg, were eventually vasodilated with hydralazine, 0.1 mg/kg intraveno...Continue Reading

References

Aug 1, 1977·British Journal of Anaesthesia·P J EvansE A Harris
Sep 1, 1992·British Journal of Anaesthesia·S B BhattM Mak
Apr 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·C L IrishR Mayer
Nov 1, 1988·Critical Care Medicine·W C ShoemakerH B Kram
Jan 1, 1987·Scandinavian Journal of Thoracic and Cardiovascular Surgery·H M KoningJ J Defauw
Jun 1, 1974·British Journal of Anaesthesia·E A HarrisB G Barratt-Boyes
Aug 1, 1983·Critical Care Medicine·K ShibutaniD V Bizzarri

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Citations

Oct 19, 2000·The Australian and New Zealand Journal of Psychiatry·E SymesJ Currie
Apr 18, 2009·Anesthesia and Analgesia·Glenn S MurphyRobert C Groom
Jan 5, 2006·European Journal of Anaesthesiology·P J Van der LindenJ-L Vincent
May 23, 2002·Perfusion·Y M GanushchakD S de Jong

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