PMID: 7035573Feb 1, 1982Paper

The relationship between T lymphocyte subsets and Ia-like antigen positive nonlymphoid cells in early stages of cutaneous T cell lymphoma

The Journal of Investigative Dermatology
J A ThomasG Goldstein

Abstract

Immunofluorescence studies were carried out in cutaneous T cell lymphoma (mycosis fungoides) in order to analyse the microanatomical relationship of the different T lymphocyte subsets (inducer and suppressor/cytotoxic cell populations) to large nonlymphoid Langerhans-type and so-called "indeterminate" or interdigitating cells. The conventional and mouse (monoclonal) antibodies were used in various combinations using fluorescein and rhodamine labeled second layers. In 5 of the 7 cases studied the dermal infiltrate consisted of numerous T (HuTLA+) lymphocytes, 80-90% of which expressed the inducer phenotype (HuTLA+,OKT4+). Most of these cells formed close contact with large cells exhibiting large amounts of Ia-like antigens. These cells corresponded to the interdigitating and indeterminate cells in the sections. By contrast, only small numbers (10-20%) of T cells of suppressor/cytotoxic type (HuTLA+,OKT8+) were seen. These did not show a close affinity to the Ia-like antigen positive nonlymphoid component but appeared to have a predilection for the epidermis. Epidermal Langerhans cells, also strongly Ia-like antigen positive, were further defined by 2 monoclonal antibodies reacting with a cortical thymocyte antigen HTA-1. Althoug...Continue Reading

Citations

Aug 1, 1987·The British Journal of Dermatology·D N Slater
Apr 1, 1983·The British Journal of Dermatology·R WillemzeC J Meijer
Nov 9, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M Der-PetrossianF Trautinger
Oct 1, 1985·The British Journal of Dermatology·R GreenwoodI Lauder
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·G JanossyG Pizzolo
Jan 1, 1987·The British Journal of Dermatology·R S TanS G Dean
Jun 1, 1983·Journal of Cutaneous Pathology·C R TaylorT H Rea
Apr 1, 1983·The British Journal of Dermatology·R WillemzeC J Meijer
Jul 1, 1986·Clinical and Experimental Dermatology·M H RustinC M Ridley
Oct 3, 1998·Experimental Dermatology·G De Panfilis
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Dec 1, 1987·Acta Pathologica Japonica·Y MizukamiA Ooi
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Jan 1, 1983·Archives of Dermatological Research·R WillemzeC J Meijer
May 1, 1985·Scandinavian Journal of Haematology·E RalfkiaerK Thomsen
Nov 1, 1986·The Journal of Investigative Dermatology·M KashiharaS Imamura

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