The Relationship between the Initial Anti-factor Xa Measurement and the Duration of Direct Oral Anticoagulant Influence in Patients Transitioning to Heparin.

Pharmacotherapy
Michelle D PlumSurabhi Palkimas

Abstract

Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) during this transition period, which removes DOAC-mediated antifactor Xa activity (d-AXA) and reflects heparin-specific activity. Currently, the duration of this influence is not well described. This study had two aims: to determine if the initial d-AXA is predictive of the duration of DOAC influence and to further characterize this influence among different patient populations. This retrospective study included adult patients admitted to UVA Medical Center between September 2016 and March 2017, with c-AXA measurements, who received apixaban or rivaroxaban within 48 hours before heparin initiation. A Pearson correlation test, Kaplan-Meier Survival Analysis, and multivariate linear regression were used to assess the relationship between initial d-AXA and duration of influence. Sixty-eight patients met inclusion criteria and were maintained on either apixaban (85%) or rivaroxaban (15%) before heparin initiation. The initial d-AXA ...Continue Reading

References

Apr 18, 2013·International Journal of Laboratory Hematology·C Eby
May 20, 2015·Thrombosis Research·D M Adcock, R Gosselin
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·Maureen A SmytheAnn K Wittkowsky
Apr 6, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jodi WendteBeau VanOverschelde
Jun 15, 2016·Journal of Thrombosis and Haemostasis : JTH·K MartinS Moll
Oct 19, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Sean G YatesRavi Sarode
Dec 7, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Andrew C FaustAnn K Wittkowsky
Sep 2, 2017·The Annals of Pharmacotherapy·Kelly A MacedoKenneth R Eugenio
Nov 24, 2018·International Journal of Laboratory Hematology·Sean Platton, Christina Hunt
Sep 17, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·L SlavikM Palova
Oct 1, 2020·The Journal of Applied Laboratory Medicine·Sydney W StricklandLindsay A L Bazydlo

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