The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases.

British Journal of Pharmacology
A Rietz, Jp Spiers

Abstract

The MMPs and their inhibitors [tissue inhibitor of MMPs (TIMPs)] form the mainstay of extracellular matrix homeostasis. They are expressed in response to numerous stimuli including cytokines and GPCR activation. This review highlights the importance of adrenoceptors and phosphoprotein phosphatases (PPP) in regulating MMPs in the cardiovascular system, which may help explain some of the beneficial effects of targeting the adrenoceptor system in tissue remodelling and will establish emerging crosstalk between these three systems. Although α- and β-adrenoceptor activation increases MMP but decreases TIMP expression, MMPs are implicated in the growth stimulatory effects of adrenoceptor activation through transactivation of epidermal growth factor receptor. Furthermore, they have recently been found to catalyse the proteolysis of β-adrenoceptors and modulate vascular tone. While the mechanisms underpinning these effects are not well defined, reversible protein phosphorylation by kinases and phosphatases may be key. In particular, PPP (Ser/Thr phosphatases) are not only critical in resensitization and internalization of adrenoceptors but also modulate MMP expression. The interrelationship is complex as isoprenaline (ISO) inhibits oka...Continue Reading

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Citations

Mar 26, 2016·Frontiers in Physiology·Priyanka PrathipatiParas K Mishra
Aug 24, 2012·Basic & Clinical Pharmacology & Toxicology·Karina C FerrazJose E Tanus-Santos
Jul 30, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Roberto SchreiberWilson Nadruz
Aug 27, 2014·Archives of Biochemistry and Biophysics·Katiucia Batista Silva Paiva, José Mauro Granjeiro
Sep 5, 2013·Oncology Reports·Jiaode JiangFei Liu
May 28, 2019·Frontiers in Molecular Neuroscience·Seham Alaiyed, Katherine Conant
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
Aug 27, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Gabriela Adriana FilipRazvan Stefan

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