The relationship between the morphological subtypes of microglia and Alzheimer's disease neuropathology.

Brain Pathology
Patrick Jarmo PaasilaGreg Trevor Sutherland

Abstract

Microglial associations with both the major Alzheimer's disease (AD) pathognomonic entities, β-amyloid-positive plaques and tau-positive neurofibrillary tangles, have been noted in previous investigations of both human tissue and mouse models. However, the precise nature of their role in the pathogenesis of AD is debated; the major working hypothesis is that pro-inflammatory activities of activated microglia contribute to disease progression. In contrast, others have proposed that microglial dystrophy with a loss of physiological and neuroprotective activities promotes neurodegeneration. This immunohistochemical study sought to gain clarity in this area by quantifying the morphological subtypes of microglia in the mildly-affected primary visual cortex (PVC), the moderately affected superior frontal cortex (SFC) and the severely affected inferior temporal cortex (ITC) of 8 AD cases and 15 age and gender-matched, non-demented controls with ranging AD-type pathology. AD cases had increased β-amyloid and tau levels compared to controls in all regions. Neuronal loss was observed in the SFC and ITC, and was associated with atrophy in the latter. A major feature of the ITC in AD was a decrease in ramified (healthy) microglia with imag...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1988·Glia·W J StreitG W Kreutzberg
May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Aug 1, 1997·Neuroscience·J J KrilH Cartwright
Oct 28, 1997·Acta Neuropathologica·A SasakiY Nakazato
May 26, 1998·Journal of Neuropathology and Experimental Neurology·B T HymanM C Irizarry
Jun 19, 1998·Brain Research. Molecular Brain Research·D ItoS Kohsaka
Dec 25, 2002·Neurobiology of Aging·Anne K VehmasJuan C Troncoso
Aug 21, 2003·Neurobiology of Aging·G M HallidayJ J Kril
Jan 20, 2004·Glia·Wolfgang J StreitD Larry Sparks
Jun 4, 2008·Journal of Neuropathology and Experimental Neurology·Diego IaconoJuan C Troncoso
Jul 8, 2008·Nature Immunology·Annett HalleDouglas T Golenbock
May 29, 2009·Neuropathology and Applied Neurobiology·C M MonoranuW Roggendorf
Dec 17, 2009·Journal of Neuropathology and Experimental Neurology·Pascal F DurrenbergerRichard Reynolds
Mar 17, 2010·Microscopy Research and Technique·Ignacio Arganda-CarrerasCarlos Ortiz-De-Solorzano
Dec 24, 2010·Journal of Neurochemistry·Greg T SutherlandJillian J Kril
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Jun 22, 2011·Alcoholism, Clinical and Experimental Research·Donna SheedyJillian J Kril
Jul 23, 2011·The American Journal of Pathology·Alberto Serrano-PozoBradley T Hyman
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Jul 10, 2012·Current Neurology and Neuroscience Reports·Jill S Goldman
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brent CameronGary E Landreth
Oct 31, 2012·Annals of Neurology·David A BennettJulie A Schneider
Dec 21, 2012·Neuropathology and Applied Neurobiology·D BocheJ A R Nicoll
Apr 23, 2013·The American Journal of Pathology·Alberto Serrano-PozoBradley T Hyman
Dec 19, 2013·Metabolic Brain Disease·Claude V DennisGreg T Sutherland
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Tasnim RahmanClaire Goldsbury
Sep 27, 2014·Acta Neuropathologica Communications·Wolfgang J StreitIngo Bechmann

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Citations

Jun 28, 2019·Cells·Diana K Franco-BocanegraDelphine Boche
Jul 28, 2019·Medicinal Research Reviews·Nour M Moussa-PachaTaleb H Al-Tel
Jan 11, 2020·Glia·Wolfgang J StreitIngo Bechmann
Sep 8, 2020·Journal of Alzheimer's Disease : JAD·Olivia G HollowayJenna M Ziebell
Sep 17, 2020·Journal of Neuroinflammation·Irina BelayaKatja M Kanninen
Apr 25, 2020·Frontiers in Neuroscience·Chelsey Jenna LeBlangJennifer Irene Luebke
Dec 29, 2020·Journal of Alzheimer's Disease : JAD·Wolfgang J StreitIngo Bechmann
Oct 23, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Alessandra C MartiniElizabeth Head
Mar 9, 2021·Journal of Neuroscience Research·Patrick Jarmo PaasilaManuel B Graeber
Mar 20, 2021·Journal of Neuroinflammation·Andrés FernándezEva Cano
Apr 4, 2021·Journal of Clinical Medicine·Alexandru CojocaruEugen Osiac
Apr 16, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Eric DyneMin-Ho Kim
Mar 17, 2021·Brain : a Journal of Neurology·Daniel AsbyJ Scott Miners
Aug 7, 2021·Scientific Reports·Diana K Franco-BocanegraDelphine Boche
Aug 19, 2021·Stroke; a Journal of Cerebral Circulation·Aminata P CoulibalyJ Javier Provencio

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