PMID: 1202916Nov 1, 1975Paper

The relationship between the nuclear DNA content in smears of aspirates and the prognosis of mucoepidermoid carcinoma

Acta Oto-laryngologica
C M Eneroth, A Zetterberg

Abstract

Cytophometric analysis of nuclear DNA content was performed in a series of mucoepidermoid carcinomas with an extreme difference in the clinical course, which was observed during a follow-up period of 6-13 years. The prerequisite for such a study was the development of a method, which made it possible to study the nuclear DNA content in tumour cells obtained at the time of diagnosis, i.e. 6-13 years ago in the present material. A special cytochemical procedure with destaining of the original Giemsa stain, refixation and subsequent Feulgen staining of the smears of aspirates in the original cytological material was developed. The cytophotometric nuclear DNA analysis of tumour cells in smears of aspirate from mucoepidermoid carcinomas showed that higher ploidy tumours (near-triploid) had a worse prognosis when compared with near-diploid tumours. These data are supported by our previous findings that a shift from a near-diploid to a near-triploid DNA content of the tumour cell nuclei was associated with the prognostic important property of invasive growth. Thus, the cytophotometric nuclear DNA analysis of aspirated tumour cells seems to give valuable information about the malignancy degree of the individual tumour, which is not pos...Continue Reading

References

Jan 1, 1973·Cytogenetics and Cell Genetics·J CervenkaR J Gorlin
Dec 1, 1969·British Journal of Urology·E H CooperR E Williams

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Citations

Dec 1, 1985·World Journal of Surgery·M BäckdahlT Löwhagen
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·P GemrydB Nordenskjöld
Jan 1, 1991·Acta Oncologica·A Zetterberg, G Forsslund
Feb 1, 1980·American Journal of Otolaryngology·A Biörklund, C M Eneroth
May 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K HamperG Seifert
Jan 1, 1976·Archives of Oto-rhino-laryngology·C M Eneroth

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