PMID: 3214947May 1, 1988Paper

The relationship between the response to growth hormone therapy and pre-treatment growth hormone secretory status

Clinical Endocrinology
P C HindmarshC G Brook

Abstract

In 35 children (22 M, 13 F) aged between 5.3 years and 10.3 years who received Somatrem therapy for 1 year there was a curvi-linear relationship between pretreatment GH sensory status (x) and response (y) (change in height velocity standard deviation score (SDS)) to therapy described by the equation y = A + B (e-Cx). A, B and C are constants. Dose of GH administered was found to be an important additional factor in determining response to therapy. This was confirmed by stepwise multiple regression which resulted in a correlation coefficient of 0.74. These data suggest that in the assessment of response to GH therapy, pretreatment height velocity and/or GH secretory status as well as dose and frequency of GH administration need to be taken into account.

References

Sep 5, 1987·British Medical Journal·P C Hindmarsh, C G Brook
May 1, 1988·Archives of Disease in Childhood·P J SmithC G Brook
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·N MaurasJ D Veldhuis
Jan 1, 1986·Acta paediatrica Scandinavica·K Albertsson-WiklandU Westgren
Nov 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W FinkelsteinL Hellman

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Citations

Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·K Albertsson-Wikland
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·L E Underwood, P A Rieser
Aug 1, 1988·Clinical Endocrinology·C G Brook
Nov 16, 2005·Hormone Research·Robert D Murray
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·T Tuvemo
May 1, 1991·Clinical Endocrinology·P C HindmarshC G Brook
Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·M Vanderschueren-Lodeweyckx

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