The fine structure of rat gastrocnemius muscle fibers has been studied after changes were induced in the basal metabolic rate (BMR) by thyroidectomy and L-thyroxine administration under anabolic conditions. Biochemical analysis of skeletal muscle mitochondrial respiration and phosphorylation from the same tissue preparations has been summarized, details having been published earlier (3). As estimated from electron micrographs, the total amount of mitochondria from thyroidectomized animals was enlarged 1.5 times over that from normal controls. The total amount of mitochondria from thyroidectomized or normal animals made hypermetabolic with thyroxine was increased 2.5 to 3.5 times over that from their corresponding controls. In all cases, there was an increase in the mitochondrial population and the profile ratio of cristae to matrix was also considerably increased, thus indicating both relative and absolute enlargements of the entire surface of the cristae per unit fiber. The major structural changes persisted for at least 3 weeks after the cessation of thyroxine treatment, by which time the elevated mitochondrial respiratory and phosphorylative activity had declined to normal values. The hypertrophy and increase in mitochondria...Continue Reading
Stimulation of amino acid incorporation into protein by isolated mitochondria from rats treated with thyroid hormones
ACCELERATED SYNTHESIS AND TURNOVER OF NUCLEAR AND CYTOPLASMIC RNA DURING THE LATENT PERIOD OF ACTION OF THYROID HORMONE
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Ultrastructural modifications of mitochondria of rat soleus muscles surgically induced to hypertrophy
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Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain mitochondria
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Thyroid hormone activates transcription from the promoter regions of some human nuclear-encoded genes of the oxidative phosphorylation system
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Thyroid hormone regulation of nuclear-encoded mitochondrial inner membrane polypeptides of the liver
Transcript levels for nuclear-encoded mammalian mitochondrial respiratory-chain components are regulated by thyroid hormone in an uncoordinated fashion
Differences in ultrastructural and metabolic profiles within the same type of fibres in various muscles of young and adult rats
Effects of thyroid hormones on skeletal muscle bioenergetics. In vivo phosphorus-31 magnetic resonance spectroscopy study of humans and rats
Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans
Cultivation in glucose-deprived medium stimulates mitochondrial biogenesis and oxidative metabolism in HepG2 hepatoma cells
Modification of nucleic acid levels per mitochondrion induced by thyroidectomy or triiodothyronine administration
Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones
The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid
A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix
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Mechanisms of adaption of hepatocytes to a chronical hypothyroidism (a cytophotometrical and morphometrical study) (author's transl)
The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation
The translation system of rat heart muscle mitochondria is stimulated following treatment with L-triiodothyronine
Effect of thyroid deficiency on oxidative phosphorylation in rat liver, kidney, and brain mitochondria
Ultrastructural changes in the chondriome during perinatal development in brown adipose tissue of rats
The formation of 'giant' mitochondria in the fibrillar flight muscles of the house fly, Musca domestica L
Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: effects of procedural manipulations
Muscular abnormalities in experimental hypothyroidism of rats with special reference to the mounding phenomenon
The low physical working capacity of thyrotoxic patients is not normalized by oral antithyroid treatment
The role of thyroid hormone and promoter diversity in the regulation of nuclear encoded mitochondrial proteins
Rapid mitochondrial enlargement in muscle as a response to triamcinolone acetonide and its relationship to the ribosomal defect
The effects of tri-iodothyronine on the synthesis of mitochondrial proteins in isolated rat hepatocytes
Interference of various antibiotics and other compounds with protein synthesis in muscle and their influence on metabolic regulation
Reversible and unilateral corticospinal tract disease secondary to autoimmune free-T3-thyrotoxicosis
Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function
Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies
Regulation of the observed metabolic adaptation and performance increase by thyroid hormones during prolonged physical training
Peripheral circulatory and metabolic consequences of thyrotoxicosis. IX. Ultrastructural changes in skeletal muscle during experimental thyrotoxicosis in the dog
Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease
A variant form of the nuclear triiodothyronine receptor c-ErbAalpha1 plays a direct role in regulation of mitochondrial RNA synthesis
Biochemical lesions of respiratory enzymes and configurational changes of mitochondria in vivo. I. The effect of fluoroacetate: a study by phase-contrast microscopy and time-lapse cinemicrography
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