PMID: 5893687Aug 1, 1965

The relationship between the structure and activity of rat skeletal muscle mitochondria after thyroidectomy and thyroid hormone treatment

The Journal of Cell Biology
R GustafssonL ERNSTER

Abstract

The fine structure of rat gastrocnemius muscle fibers has been studied after changes were induced in the basal metabolic rate (BMR) by thyroidectomy and L-thyroxine administration under anabolic conditions. Biochemical analysis of skeletal muscle mitochondrial respiration and phosphorylation from the same tissue preparations has been summarized, details having been published earlier (3). As estimated from electron micrographs, the total amount of mitochondria from thyroidectomized animals was enlarged 1.5 times over that from normal controls. The total amount of mitochondria from thyroidectomized or normal animals made hypermetabolic with thyroxine was increased 2.5 to 3.5 times over that from their corresponding controls. In all cases, there was an increase in the mitochondrial population and the profile ratio of cristae to matrix was also considerably increased, thus indicating both relative and absolute enlargements of the entire surface of the cristae per unit fiber. The major structural changes persisted for at least 3 weeks after the cessation of thyroxine treatment, by which time the elevated mitochondrial respiratory and phosphorylative activity had declined to normal values. The hypertrophy and increase in mitochondria...Continue Reading

References

Jun 5, 1954·Nature·J B CHAPPELL, S V PERRY
Mar 25, 1957·The Journal of Biophysical and Biochemical Cytology·K R PORTER, G E PALADE
Jan 1, 1961·Experimental Cell Research·G F AZZONEG SZABOLCSI
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Aug 5, 1961·Biochimica Et Biophysica Acta·M J FLETCHER, D R SANADI
Feb 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·D J LUCK
Jul 30, 1963·Biochimica Et Biophysica Acta·C C WIDNELL, J R Tata
Aug 30, 1963·Science·J R BRONK
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·M J KARNOVSKY

Citations

Aug 25, 1978·Journal of Neurology·S BassiL Frattola
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·H Teräväinen
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M J Dauncey, D L Ingram
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J RassatH Themann
Jan 1, 1971·Virchows Archiv. A: Pathology. Pathologische Anatomie·Z GoriA Cao
Jan 1, 1973·Internationale Zeitschrift für angewandte Physiologie, einschliesslich Arbeitsphysiologie·R B Armstrong, P D Gollnick
Jul 1, 1995·Neuroscience and Behavioral Physiology·A P Bozhko, I V Gorodetskaya
Jan 1, 1989·Archives of Biochemistry and Biophysics·A Mutvei, B D Nelson
Mar 1, 1990·Respiration Physiology·A H SillauN Reyes
Apr 1, 1996·Steroids·C DemonacosC E Sekeris
Mar 1, 1989·Molecular and Cellular Endocrinology·F GogliaA Barletta
Nov 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G R SimonP Morrison
Jun 13, 2008·Journal de la Société de biologie·Chantal Wrutniak-CabelloG Cabello
Jan 25, 1979·The New England Journal of Medicine·K Sterling
Jul 1, 1969·The Journal of Cell Biology·W W Franke, W Schinko
Jan 1, 1971·The Journal of Cell Biology·N J Gross
Jun 1, 1978·The Journal of Cell Biology·S JakovcicM Rabinowitz
Mar 1, 1989·European Journal of Biochemistry·A MutveiB D Nelson
May 1, 1987·Biological Reviews of the Cambridge Philosophical Society·M D Brand, M P Murphy
Nov 1, 1978·Acta Physiologica Scandinavica·J OrlanderA Aniansson
Nov 1, 1968·Annals of the Rheumatic Diseases·W J Fessel
May 1, 1983·Journal of Clinical Pathology·A A KhaleeliR H Edwards
Sep 7, 2001·The Journal of Clinical Investigation·V LebonG I Shulman
Oct 15, 1976·Pflügers Archiv : European journal of physiology·T LeoF Goglia
Dec 18, 2004·Journal of Cellular Physiology·L BahiR Ventura-Clapier
May 16, 1985·Biochemical and Biophysical Research Communications·C Côté, D Boulet
Jan 1, 1973·Journal of Ultrastructure Research·L P McCallister, E Page
Jul 1, 1977·Archives of Biochemistry and Biophysics·S S KatyareA Sreenivasan
Nov 1, 1969·Journal of Ultrastructure Research·T Barnard, O Lindberg
Apr 5, 1976·Biochemical and Biophysical Research Communications·T C Evans, F L Hoch
Mar 1, 1970·Journal of Theoretical Biology·E Gruenstein, J Wynn
Sep 1, 1984·Archives of Biochemistry and Biophysics·K Shivakumar, J Jayaraman
Jan 1, 1984·Archives of Biochemistry and Biophysics·B D NelsonV Joste
Nov 17, 1967·Biochemical and Biophysical Research Communications·J B Peter, L D Lee
Oct 1, 1981·Experimental and Molecular Pathology·D V UnverferthN Baba
Apr 1, 1969·Experimental and Molecular Pathology·Z GoriM Pollera
Jan 1, 1978·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·H L Schwartz, J H Oppenheimer
Sep 1, 1980·The Journal of Pathology·R O McKeranW G Mair
Jul 1, 1984·Muscle & Nerve·R H FittsB R Unsworth
Sep 2, 1975·Biochemical and Biophysical Research Communications·R L Terjung
Jul 19, 2005·Trends in Biochemical Sciences·Jamshed R Tata
Mar 28, 2012·Biochimica Et Biophysica Acta·Jamshed R Tata
Jul 8, 1980·Biochimica Et Biophysica Acta·J McMillin-WoodM L Entman
Jul 2, 1966·Nature·D HaldarT S Work
Jan 1, 1996·Ultrastructural Pathology·J LloretaS Serrano
Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S A FalkJ D Conger
Feb 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Treacey E SheehanDavid A Hood
Aug 1, 1969·Circulation Research·D A Piatnek-Leunissen, R L Leunissen
Oct 28, 2011·American Journal of Physiology. Cell Physiology·Martin PicardYan Burelle
Aug 9, 2018·Pharmacological Reviews·T D MüllerM H Tschöp
Apr 30, 2014·American Journal of Physiology. Heart and Circulatory Physiology·John M HollanderDanielle L Shepherd
Jul 7, 1995·The Journal of Biological Chemistry·C WrutniakJ Ghysdael
Jan 1, 1973·The International Journal of the Addictions·E M PattisonH O Doerr
Feb 1, 1996·Scandinavian Journal of Medicine & Science in Sports·A Viru
Jul 3, 2016·Molecular and Cellular Biochemistry·Rogério Faustino RibeiroIvanita Stefanon
Dec 14, 2018·Frontiers in Physiology·Thiago Montes FidaleElmiro Santos Resende
Feb 1, 1976·CRC Critical Reviews in Toxicology·A ReithH P Rohr
Jan 1, 1970·Pflügers Archiv : European journal of physiology·H Kraus, R Kirsten
Mar 1, 1980·Acta Neurologica Scandinavica·S N RaoS Misra
Jan 1, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H Shulte-Wissermann, E Straub
Jun 1, 1984·Acta Ophthalmologica·Z Kamieniecka, O Sjö
May 1, 1977·The American Journal of Physiology·W W Winder, J O Holloszy
Dec 1, 1991·The American Journal of Physiology·P KaminskyM Duc
Dec 13, 2017·Endocrine Regulations·M HedayatiS Niazmand

Related Concepts

Electron Microscopy
Mitochondria
Muscle
Oxidative Phosphorylation
Thyroidectomy
Novothyral

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