PMID: 2118207Jan 1, 1990Paper

The relationship between thermodynamics and the toxicity of gadolinium complexes

Magnetic Resonance Imaging
W P CacherisS M Rocklage

Abstract

The suitability of gadolinium complexes as magnetic resonance imaging contrast agents depends on a number of factors. A thermodynamic relationship to toxicity exists if one assumes that the chemotoxicity of the intact complex is minimal but that the toxicity of the components of the complex (free metal and uncomplexed ligands) is substantial. Release of Gd3+ from the complex is responsible for the toxicity associated with gadolinium complexes; this release appears to be a consequence of Zn2+, Cu2+, and Ca2+ transmetallation in vivo. This hypothesis is supported by acute toxicity experiments, which demonstrate that despite a 50-fold range of LD50 values for four Gd complexes, all become lethally toxic when they release precisely the same quantity of Gd3+, and by subchronic rodent toxicity experiments, which demonstrate a set of gross and microscopic findings similar to those known to be caused by Zn2+ deficiency. Finally, this hypothesis predicts that subtle changes in formulation can further enhance the intrinsic safety of these complexes.

References

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Citations

Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·N M RofskyA W Litt
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·A N Oksendal, P A Hals
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·S M Rocklage, A D Watson
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SaeedC B Higgins
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L Vander ElstR N Muller
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Dec 21, 2004·European Radiology·Judith A W WebbUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
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Sep 25, 2008·Journal of Medical Imaging and Radiation Oncology·A J van der Molen

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