The Relationship Between Tumor Glucose Metabolism and Host Systemic Inflammatory Responses in Patients with Cancer: A Systematic Review

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ross D DolanDonald C McMillan

Abstract

One of the most important and long recognized characteristics of tumor cells is their dysregulated cellular energetics with anaerobic driven glucose uptake. In patients with cancer, the prognostic value of the systemic inflammatory response has been well established, and the recent combination of PET and CT scanning combines the assessment of tumor physiologic activity with detailed anatomic localization. The aim of this study was to perform a systematic review of the assessment of the relationship between both the tumor and the host inflammatory responses using PET/CT. Methods: An extensive literature review using targeted subject headings was performed in the U.S. National Library of Medicine, the Excerpta Medica database, and the Cochrane Database of Systematic Reviews on March 31, 2018. On completion of the online search, the title and abstracts of each identified study were examined for relevance. Studies with duplicate datasets, not available in English, and that did not have full text availability were excluded. Full texts of relevant articles were obtained and were then examined to identify any further relevant articles. Results: Twelve studies containing 2,588 patients were included in the final analysis. All of the in...Continue Reading

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Citations

Nov 4, 2020·Pharmacological Reports : PR·Tamhida Masi, Bhoomika M Patel
Jul 20, 2021·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Massimiliano CasaliAlberto Signore
May 30, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Romain-David SebanLaurent Dercle

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