The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples

BJOG : an International Journal of Obstetrics and Gynaecology
Peter S-Y YehLawrence W M Impey

Abstract

To examine the relationship between umbilical cord pH at term and serious neonatal outcomes. Observational cohort study. Deliveries within the Oxford Radcliffe Hospital NHS Trust between 1991 and 2009. In all, 51,519 singleton, term, nonanomalous live neonates with validated umbilical cord arterial pH values. Absolute risks, relative risks with 95% confidence intervals, and numbers needed to harm were calculated for different levels of arterial pH across the entire range. Neonatal encephalopathy with seizures and/or death, encephalopathy within 24 hours of birth, 5-minute Apgar scores and neonatal unit admission. The median arterial pH was 7.22, interquartile range 7.17-7.27. The absolute risk of an adverse neurological outcome was significantly increased below 7.10 (0.36%) and was lowest between 7.26 and 7.30 (0.16%). Even below 7.00, the risk was only 2.95%. However, more than 75% of neonates with neurological outcomes examined, including seizures within 24 hours of birth, had a pH above 7.10. A small increase in risk was evident at higher pH levels. The threshold pH for adverse neurological outcomes is 7.10 and the 'ideal' cord pH is 7.26-7.30. Above 7.00, however, neonatal acidaemia is weakly associated with adverse outcome...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·T M GoodwinR H Paul
Jul 1, 1989·American Journal of Obstetrics and Gynecology·J DennisP Johnson
Apr 1, 1988·The Journal of Pediatrics·K B Nelson
Dec 1, 1994·British Journal of Obstetrics and Gynaecology·J WestgateK R Greene
Jul 16, 1997·JAMA : the Journal of the American Medical Association·J K Grether, K B Nelson
Sep 10, 1998·American Journal of Obstetrics and Gynecology·K B Nelson, J K Grether
Nov 20, 1998·American Journal of Obstetrics and Gynecology·T IkedaS D Park
Dec 4, 1998·BMJ : British Medical Journal·N BadawiF J Stanley
Aug 22, 2000·Archives of Disease in Childhood·A Johnson
Nov 4, 2000·Pediatrics·E LiebermanA Cohen
Jun 28, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·L ImpeyO Sheil
Jan 5, 2002·Obstetrics and Gynecology·D N Jordan, J L Jordan
Dec 4, 2003·JAMA : the Journal of the American Medical Association·Yvonne W WuThomas B Newman
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Rahi VictoryBryan Richardson
Jan 2, 2008·American Journal of Obstetrics and Gynecology·Lawrence W M ImpeyPat Doyle
Jul 1, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tamis W PinMary P Galea
Dec 17, 2008·American Journal of Obstetrics and Gynecology·Ernest M GrahamHarold E Fox
Sep 16, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·G A B KroK G Rosén

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Citations

Jan 15, 2014·BMC Pregnancy and Childbirth·Václav ChudáčekLenka Lhotská
Aug 2, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S MarretA Chadie
Jul 9, 2014·Archives of Gynecology and Obstetrics·Antonio Hernández-MartínezMilagros Molina-Alarcón
Feb 15, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Catherine E AikenJames Trussell
Dec 24, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Amar BhideGanesh Acharya
Jan 1, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V JadasUNKNOWN et le réseau de périnatalité de Haute-Normandie
Jan 14, 2016·Early Human Development·Mirta StarčevićAida Salihagić Kadić
Dec 8, 2015·American Journal of Obstetrics and Gynecology·Liv Knutzen, Lawrence Impey
Oct 8, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mahdi SheikhElaheh Amini
Jan 21, 2016·The Journal of Obstetrics and Gynaecology Research·Maria Laura AnnunziataMarta Campanile
Feb 5, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Antoniya GeorgievaChristopher W G Redman
Aug 1, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Barry S SchifrinBrian Koos
Mar 13, 2016·Archives of Gynecology and Obstetrics·E KuehnleIsmini Staboulidou
Jun 14, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·D J R Hutchon
Jun 14, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·L Impey
Dec 5, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·A PyykönenA-M Tapper
Jul 30, 2015·Medical & Biological Engineering & Computing·Hernâni GonçalvesJoão Bernardes
Jan 30, 2014·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Thea Bowler, Michael Beckmann
Jun 17, 2015·Medical Education·Catherine E AikenAndrew Prentice
Sep 1, 2015·American Journal of Obstetrics and Gynecology·Alison G Cahill
Apr 2, 2015·American Journal of Obstetrics and Gynecology·Liv KnutzenLawrence Impey
Jun 13, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·C E AikenJ H Bamber
Dec 3, 2014·American Journal of Obstetrics and Gynecology·Abigail R AikenJames G Scott
Dec 29, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yvonne M O'Brien, Deirdre J Murphy
Dec 17, 2014·International Journal of Obstetric Anesthesia·Z Y StrouchA S Habib
Jun 4, 2016·American Journal of Obstetrics and Gynecology·Bethany A Sabol, Aaron B Caughey
Jun 23, 2016·Obstetrics and Gynecology·David Hutchon, Susan Bewley
Oct 30, 2016·American Journal of Obstetrics and Gynecology·Catherine E AikenJeremy C Brockelsby
Oct 6, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·E R AllansonJ E Dickinson
Oct 21, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sabina Martí GamboaSergio Castán Mateo
Nov 26, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anne A C van TeteringS Guid Oei
Dec 8, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Natascia GiulianoDomenico Arduini
Apr 6, 2016·IEEE Journal of Biomedical and Health Informatics·Jiri SpilkaMuriel Doret
May 6, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Uzma Tahir MahmoodDeirdre J Murphy
Jun 21, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca CrovettoBarbara Acaia
Jul 14, 2017·Journal of Midwifery & Women's Health·Katie PageMamie Guidera
Jan 18, 2018·Archives of Gynecology and Obstetrics·Sivan Zuarez-EastonRaed Salim
Mar 2, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Emma R AllansonJan E Dickinson
Mar 8, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Liv KnutzenLawrence Impey
Mar 27, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·H A FreyM B Landon
Apr 11, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Liv KnutzenLawrence Impey

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