The relationship between vitamin D and chemotherapy-induced toxicity - a pilot study.

British Journal of Cancer
D KitchenN Rohatgi

Abstract

There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further. From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin. A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78). This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.

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Citations

Aug 6, 2013·Current Opinion in Supportive and Palliative Care·Kurt A Kennel, Matthew T Drake
May 6, 2020·Journal of Evidence-based Medicine·Kanhatai ChiengthongRonpichai Chokesuwattanaskul
Jun 21, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·N OosteromS M F Pluijm

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