The relationship between voxel-based metrics of resting state functional connectivity and cognitive performance in cognitively healthy elderly adults

Brain Imaging and Behavior
Haobo ZhangWei Wen

Abstract

In previous studies, resting-state functional connectivity (FC) metrics of specific brain regions or networks based on prior hypotheses have been correlated with cognitive performance. Without constraining our analyses to specific regions or networks, we employed whole-brain voxel-based weighted degree (WD), a measure of local FC strength, to be correlated with three commonly used neuropsychological assessments of language, executive function and memory retrieval in both positive and negative directions in 67 cognitively healthy elderly adults. We also divided voxel-based WD into short-ranged and long-ranged WDs to evaluate the influence of FC distance on the WD-cognition relationship, and performed three validation tests. Our results showed that for language and executive function tests, positive WD correlates were located in the frontal and temporal cortices, and negative WD correlates in the precuneus and occipital cortices; for memory retrieval, positive WD correlates were located in the inferior temporal cortices, and negative WD correlates in the anterior cingulate cortices and supplementary motor areas. An FC-distance-dependent effect was also observed, with the short-ranged WD correlates of language and executive functi...Continue Reading

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Methods Mentioned

BETA
SMA

Software Mentioned

AFNI
COWAT
Graph - theoRETical Network Analysis toolkit ( GRETNA )
BrainNet
SPM8
AlphaSim
BrainNet viewer
MATLAB
xjView

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