The Relationship Between Vulvovaginal Candidiasis and Provoked Vulvodynia: A Systematic Review

The Journal of Sexual Medicine
Peter LeusinkAntoine L Lagro-Janssen

Abstract

Provoked vulvodynia (PVD) is a chronic vulvar pain condition affecting up to 8.3% of the female population. Despite many years of research, no clear cause for PVD has been identified. Several risk factors have been studied, including vulvovaginal candidiasis (VVC). However, to date, the role of Candida infections in PVD has remained unclear. VVC and PVD have an overlap of symptoms that may contribute to diagnostic inaccuracy and mistreatment. To systematically review the literature on the relationship between VVC and PVD. Cohort and case-control studies were included that compared women with PVD with healthy controls with respect to the presence of a history of Candida vulvovaginitis. PVD had to be diagnosed by Friedrich's criteria or the International Society for the Study of Vulvovaginal Disease criteria. The inclusion process as well as the quality appraisal of the studies, using the Newcastle-Ottawa Quality Assessment Scale, were performed independently by 2 authors. Outcomes of the population-based case-control studies were listed as odds ratio. Outcomes of the pathophysiological studies were based on local pro-inflammatory responses on Candida in vitro. We included a total of 14 studies, both population and clinic-based c...Continue Reading

Citations

Sep 11, 2019·Chinese Medical Journal·Feng-Juan Wang, Zhao-Hui Liu
Aug 27, 2019·Frontiers in Molecular Neuroscience·Christine Mary BarryRainer Viktor Haberberger
Jan 9, 2021·International Urogynecology Journal·Arif AydınMehmet Giray Sönmez
Jul 6, 2021·Frontiers in Cellular and Infection Microbiology·Jorma Paavonen, David A Eschenbach
Jul 23, 2021·Journal of Women's Health·Andrea Boyd TresslerOluwatosin Goje

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