PMID: 8609684Apr 17, 1996Paper

The relationship of bone and blood lead to hypertension. The Normative Aging Study

JAMA : the Journal of the American Medical Association
H HuA Rotnitzky

Abstract

To test the hypothesis that long-term lead accumulation, as reflected by levels of lead in bone (as opposed to blood which reflects recent lead exposure), is associated with an increased odds of developing hypertension. Case-control study of participants in the Veterans Administration (now Department of Veterans Affairs) Normative Aging Study, a 30-year longitudinal study of men. Of 1171 active subjects who were seen between August 1991 and December 1994, 590 (50%) participated in this investigation and had data on all variables of interest. Hypertension was defined as taking daily medication for the treatment of hypertension or systolic blood pressure higher than 160 mm Hg or diastolic blood pressure of 96 mm Hg or higher during the time of examination. Levels of lead in the tibia (representing cortical bone) and the patella (representing trabecular bone) were measured in vivo with a K x-ray fluorescence (KXRF) instrument. Levels of lead in blood were measured by graphite furnace atomic absorption spectroscopy. Blood lead levels were low, ranging from less than 0.05 to 1.35 micromol/L (<1 to 28 microgram/dL), with a mean (SD) of 0.30 (0.20) micromol/L (6.3[4.1] microgram/dL). Bone lead levels were similar to those described in...Continue Reading

Citations

May 29, 2014·Vascular Health and Risk Management·Michael SponderJeanette Strametz-Juranek
Jan 24, 2009·Environmental Health Perspectives·Sung Kyun ParkMarc G Weisskopf
Mar 29, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jennifer A JamiesonCarla G Taylor
Apr 1, 1997·Environmental Health Perspectives·S HanJ D Bogden
Sep 25, 1997·Environmental Health Perspectives·M Loghman-Adham
Dec 16, 1998·Occupational and Environmental Medicine·L StokesW E Kaye
Mar 17, 1999·American Journal of Public Health·S A KorrickF E Speizer
May 26, 1999·Environmental Health Perspectives·K BrueningJ D Bogden
Apr 7, 2000·Environmental Health Perspectives·G M Scelfo, A R Flegal
Jul 18, 2000·Occupational and Environmental Medicine·M J BrownM Hernandez-Avila
Feb 15, 2001·Environmental Health Perspectives·H Hu
Oct 4, 2002·Environmental Health Perspectives·Brian GulsonKay Waite
Feb 5, 2000·Environmental Health Perspectives·S H Wilson
Feb 9, 2002·Environmental Health Perspectives·David O CarpenterDavid C Spink
Aug 4, 2004·Environmental Health Perspectives·Charles LinHoward Hu
Aug 4, 2004·Environmental Health Perspectives·Shirng-Wern TsaihHoward Hu
Aug 4, 2004·Environmental Health Perspectives·James R CampbellJ Edward Puzas
Dec 7, 2005·Environmental Health Perspectives·Fernando BarbosaPatrick J Parsons
May 19, 2006·International Journal of Environmental Research and Public Health·Vladislav KondrashovStephen J Rothenberg
Nov 17, 2006·Environmental Health Perspectives·Sung Kyun ParkHoward Hu
Apr 14, 2007·Environmental Health Perspectives·Howard HuBrian S Schwartz
Apr 14, 2007·Environmental Health Perspectives·Michael J KosnettAlan Woolf
Apr 14, 2007·Environmental Health Perspectives·Ana Navas-AcienStephen J Rothenberg
Aug 10, 2007·Environmental Health Perspectives·Junenette L PetersHoward Hu
Aug 10, 2007·Environmental Health Perspectives·Florence T WangRobert O Wright
Dec 19, 2007·Environmental Health Perspectives·Todd PerlsteinHoward Hu
Feb 22, 2008·Environmental Health Perspectives·Brooks B GumpDouglas A Granger
Apr 7, 2009·Environmental Health : a Global Access Science Source·Naila KhalilJane A Cauley
Jun 17, 2009·Journal of Occupational and Environmental Medicine·Huiling NieHoward Hu
Jan 13, 2010·Environmental Health Perspectives·Robert O WrightAndrea Baccarelli
Jan 13, 2010·Environmental Health Perspectives·Junenette L PetersRosalind J Wright
Feb 4, 2010·Environmental Health Perspectives·Franco ScinicarielloUNKNOWN Centers for Disease Control and Prevention/National Cancer Institute National Health and Nutrition Examination Survey III Ge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.