The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study.

Ophthalmology
Barbara E K KleinRonald Klein

Abstract

To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval. Longitudinal population-based study of age-related eye diseases. Beaver Dam Eye Study participants. Persons aged 43 to 86 years participated in the baseline examination in 1988-1990. Participants were followed up at 5-year intervals after the baseline examination. Examinations consisted of ocular examination with lens and fundus photography, medical history, measurements of blood pressure, height, and weight. Values of risk variables were updated, and incidences of early and late AMD were calculated for each 5-year interval. Odds ratios were computed using discrete linear logistic regression modeling with generalized estimating equation methods to account for correlation between the eyes and multiple intervals. Age-related macular degeneration. After adjusting for age and sex, neither cataract nor cataract surgery was associated with increased odds for developing early AMD. Further adjusting for high-risk gene alleles (CFH and ARMS2) and other possible risk factors did not materially affect the odds ratio (OR). However, cataract surgery was associated with incidence of late AMD (OR 1.9...Continue Reading

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Citations

May 31, 2014·American Journal of Ophthalmology·Yasuo NodaTakashi Ueta
Sep 5, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorKaren Blessing
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Jun 24, 2010·Ophthalmology·Barbara E K KleinRonald Klein
Jul 4, 2017·Acta Ophthalmologica·Jau-Der HoHerng-Ching Lin
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Aug 24, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christina A KorbNorbert Pfeiffer

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