The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells

International Reviews of Immunology
M A BorrelloR P Phipps

Abstract

For decades, numerous investigators have reported derivation of macrophage-like cells from CD5(+) pre-B cell lymphomas. Recently, it has become clear that biphenotypic CD5(+) B/macrophage cells are not a spurious result of malignancy. Indeed, the existence of normal biphenotypic cells with CD5(+) B lymphocyte and macrophage characteristics has been demonstrated in the mouse. This review considers normal B/macrophage cell function in an evolutionary context where a primitive, flexible cell type could perform dual roles in adaptive and innate immunity.

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Citations

Jan 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jorge VeraFrancisco Lozano
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Naoki KoideTakashi Yokochi
Jun 5, 2012·Pathology, Research and Practice·Caterina DefendentiPiercarlo Sarzi-Puttini
Apr 13, 2011·Current Opinion in Immunology·Gloria SoldevilaFrancisco Lozano
Dec 6, 2008·Molecular and Cellular Endocrinology·Julian M W Quinn, Hasnawati Saleh
Jul 28, 2005·International Journal of Experimental Pathology·Cristina Stewart Bittencourt BogsanMario Mariano
Jun 22, 2007·Immunity·Richard R HardyKenneth Dorshkind
Oct 9, 2002·Immunological Reviews·Samuel W FrenchMichael A Teitell
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard R Hardy
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tatsiana AudzevichDerek W Gilroy
Dec 9, 2020·Cells·María Velasco-de AndrésFernando Aranda

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