The Relationship of Circular RNAs With Ovarian Endometriosis

Reproductive Sciences
Xiao-Xuan XuJing-he Lang

Abstract

Circular RNAs (circRNAs) are involved in the pathogenesis of many diseases, although their expression pattern and role in endometriosis remains unknown. Therefore, here, we profiled the expression patterns of circRNAs in ovarian ectopic and paired eutopic endometria as well as constructed a circRNA-miRNA-mRNA network. Circular RNA and messenger RNA (mRNA) expression profiles were assessed by a microarray analysis in 4 patients. Quantitative real-time polymerase chain reaction (qRT-PCR) validation of 8 circRNAs and mRNAs was conducted in another 37 patients. We detected 1258 up- and 1061 downregulated circRNAs as well as 1900 up- and 2535 downregulated mRNAs between the ectopic and eutopic endometria. Functional analysis suggested that most differentially expressed mRNAs participate in immune-inflammatory responses and cell cycle regulation. The qRT-PCR validation results for 5 circRNAs ( circ_0004712, circ_0002198, circ_0003570, circ_0008951, and circ_0017248) and 8 mRNAs ( SCN3B, ENTPD1, IL16, BACH2, C3, CKS2, G0S2, and PGRMC1) matched the microarray results. On basis of target prediction, we constructed a circRNA-miRNA-mRNA network. This revealed the primary roles of cancer-related, purine metabolism, glycerophospholipid meta...Continue Reading

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Citations

Sep 5, 2019·Journal of Ovarian Research·Zahra ShabaninejadHamed Mirzaei
May 31, 2019·Molecular Genetics & Genomic Medicine·Dandan WangQing Yang
Jan 3, 2020·Digestive Diseases and Sciences·Han-Xi DingYuan Yuan
Jun 11, 2020·Cancer Cell International·Huixin SongQuan Liao
Oct 7, 2020·Biomarkers in Medicine·Parisa M DanaZatollah Asemi
Nov 6, 2020·Reproductive Biology and Endocrinology : RB&E·Yalan MaLianwen Zheng
Mar 6, 2021·Frontiers in Oncology·Fang JianPan Zhaoji
Jun 15, 2021·Frontiers in Endocrinology·Jiajie TuZhiying Yu

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