The relationship of comorbidities to mortality and cause of death in patients with differentiated thyroid carcinoma

Scientific Reports
Young Ki LeeEun Jig Lee

Abstract

Understanding how comorbidities contribute to death in cancer patients is becoming an important topic. The present study assessed the role of comorbidities in overall mortality and causes of death in patients with differentiated thyroid carcinoma (DTC). This retrospective cohort study included 2070 patients who underwent thyroidectomy for DTC at a single institution between 2002 and 2005. Probabilities of overall, DTC-specific and other-cause death were examined according to the number of comorbidities, with consideration for competing events. The estimated 15-year cumulative incidences of overall, DTC-specific, and other-cause death were 7.3%, 1.6%, and 5.7%, respectively. Taking the group without comorbidities as a reference, we found that the group with 1-2 comorbidities and the group with ≥3 comorbidities had higher probabilities of other-cause death (subhazard ratios = 2.48 and 9.41, respectively; p < 0.01) and consequently shorter overall survival (hazard ratio = 1.95 and 5.33, respectively; p < 0.01), with adjustment for age, sex, and tumor-node-metastasis classification. In contrast, the probability of DTC-specific death was reduced in patients with ≥3 comorbidities (subhazard ratio = 6.81e-10, p < 0.01). For overall de...Continue Reading

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Citations

Mar 17, 2020·Frontiers in Endocrinology·Junyi ZhangShen Qu
Feb 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Naykky Singh Ospina, Maria Papaleontiou
Mar 26, 2021·Thyroid : Official Journal of the American Thyroid Association·Maria PapaleontiouMegan R Haymart
Aug 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Eun Kyung LeeYuh-Seog Jung

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