PMID: 9161767May 1, 1997Paper

The relationship of endogenous cortisol to psychiatric disorder: a review

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
S J KiralyG Dimitrova

Abstract

To focus on hypothalamic-pituitary-adrenal (HPA) axis activity, especially endogenous hypercortisolemia, to study its role in the maintenance of psychiatric illness, and to entertain the probability that the elderly are vulnerable. Case presentation, clinical and research literature review, and theoretical discussion. Clinical and research evidence overwhelmingly suggest that hypercortisolemia is toxic to the hippocampus. Some research supports the position that it can be a treatable perpetuating factor in a subset of affective disorders and psychoses. Pharmacological treatments to correct hypercortisolemia have been used by endocrinologists. Hypercortisolemic treatment-resistant and nontreatment-resistant psychoses and affective disorders have been successfully treated by a small number of researchers who remain interested in this subject. Data pertaining to geriatric psychoses may be germane but are sparse. It behooves us to research diagnostic methods pertaining to psychoses and affective disorders associated with hypercortisolemic states. Very little research is available, but we must be alert to the possibility that the elderly are more susceptible to cortisol endotoxicosis than the younger adult population. Without accura...Continue Reading

References

Jan 1, 1979·Annual Review of Neuroscience·B S McEwenD W Pfaff
Oct 1, 1977·Journal of Computer Assisted Tomography·E R HeinzA Haenggeli
Jan 1, 1978·Journal of Computer Assisted Tomography·J BentsonG Wilson
Apr 1, 1992·Acta Psychiatrica Scandinavica·A C SwannE Robins
Jul 1, 1992·The American Journal of Psychiatry·R C Young, G L Klerman
May 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B E Murphy
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·D FilipiniB Dubrovsky
Oct 1, 1991·The American Journal of Psychiatry·G W Arana
Oct 1, 1990·Archives of General Psychiatry·O M WolkowitzD Pickar
Feb 1, 1991·The American Journal of Physiology·R D Specian, M G Oliver
Oct 1, 1990·The American Journal of Psychiatry·O M WolkowitzD Pickar
Apr 6, 1985·Lancet·A Angeli, R Frairia
Jan 1, 1985·Journal of Psychiatric Research·A F SchatzbergJ O Cole
Jul 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P LinkowskiE Van Cauter
Jan 1, 1988·Annals of the New York Academy of Sciences·A F Schatzberg, A J Rothschild
Oct 1, 1988·Archives of General Psychiatry·C L RavarisT Brinck-Johnsen
Sep 24, 1987·The New England Journal of Medicine·N Sonino
Nov 1, 1987·Neurobiology of Aging·P D Coleman, D G Flood
Jan 1, 1986·Psychoneuroendocrinology·J F GredenN Genero
Jan 1, 1985·Psychosomatics·K G KramlingerL L Leonard
Apr 1, 1968·Journal of Comparative and Physiological Psychology·J M Weiss
Mar 1, 1984·Archives of General Psychiatry·D R RubinowP W Gold
Nov 18, 1982·The New England Journal of Medicine·T S JensenB Weile
Feb 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·S I Cohen
Dec 1, 1994·Hormones and Behavior·H UnoJ Holden
Jan 1, 1995·Journal of Neuroendocrinology·E A YoungJ Kottak
Jun 1, 1995·The American Journal of Psychiatry·M D Beale, G W Arana
Feb 1, 1995·The American Journal of Psychiatry·G W AranaM Molloy
Jun 1, 1993·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·W Gnam, A J Flint
Sep 1, 1962·Journal of Psychiatric Research·J L GIBBONS, P R McHUGH
Jun 1, 1964·Archives of General Psychiatry·J L GIBBONS

❮ Previous
Next ❯

Citations

Oct 27, 2004·Expert Opinion on Pharmacotherapy·Pauline S Powers, Carlos Santana
May 31, 2001·Journal of the American Geriatrics Society·U G CunhaS A Rigueirinho
Jul 16, 2008·CNS Spectrums·Jyotsna Nair, Sarbjot Singh Ajit
Jun 14, 2003·The Neurologist·R C Packard
Jun 10, 2014·Pharmacological Reports : PR·Grażyna BiałaBarbara Budzyńska
Jul 10, 2008·Journal of Clinical and Experimental Neuropsychology·Benzion BeilinYehuda Shavit
Jun 28, 2005·International Journal of Psychiatry in Medicine·Michael A Kiraly, Stephen J Kiraly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.