The relationship of endogenous estrogen to bone density and bone area in normal postmenopausal women

American Journal of Epidemiology
J A CauleyD Sashin

Abstract

The relationship of endogenous concentrations of estrogen, in particular estrone, to the dominant radial bone density and bone area was examined in 78 normal postmenopausal women (mean age 57 years). The women were a subset of a population participating in a clinical trial designed to determine the effects of walking on bone loss. The data reported here were collected at baseline prior to randomization. Radial cortical bone density and bone area were measured at 30 per cent of the distance between the wrist and the elbow in the dominant arm. Estrone levels obtained by extraction and column chromatography were measured by radioimmunoassay. Estrone concentrations were cross-sectionally related to both radial bone density (r = 0.39, p less than 0.001) and bone area (r = 0.39, p less than 0.001). This relationship was independent of age, number of years since onset of menopause, and degree of obesity. In multiple regression analysis, estrone levels accounted for 15 per cent of the variance in bone density and bone area in this population. These results suggest that measurement of estrone in normal postmenopausal women may assist in the identification of women who are at high risk for osteoporosis and, thus, possible candidates for ...Continue Reading

Citations

Apr 1, 1992·Calcified Tissue International·M DanielD T Drinkwater
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J F HuT C Campbell
Feb 27, 1997·The New England Journal of Medicine·Y ZhangD T Felson
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K StoneS R Cummings
Feb 13, 2001·American Journal of Epidemiology·Y ZhangD P Kiel
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Silvano AdamiOmbretta Di Munno
Jun 16, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A DevineR L Prince
Oct 7, 2004·American Journal of Physiology. Endocrinology and Metabolism·I M DickR L Prince
Nov 1, 1992·Postgraduate Medical Journal·S MurphyJ E Compston
Feb 12, 1987·The New England Journal of Medicine·J L Kelsey, S Hoffman
Feb 15, 2001·The New England Journal of Medicine·M Clemons, P Goss
Sep 6, 2013·Calcified Tissue International·Mattias CallréusKristina Akesson
Feb 6, 2013·Breast Cancer Research and Treatment·Xinhua QuKerong Dai
Sep 17, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Katharine M N LeeKathryn B H Clancy
Feb 19, 1999·Journal of Epidemiology and Community Health·B K JacobsenG Kvåle
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·H YoshitakeM Noda
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D ChapurlatP D Delmas
Jan 1, 1987·Genetic Epidemiology·L BeggC G Watson
Aug 12, 2005·Journal of the American College of Nutrition·Wen-Huey WuTzong-An Wang
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew L CookeWilliam D Leslie
Apr 23, 2011·Breast Cancer Research and Treatment·Joohon SungKayoung Lee
May 23, 2015·Journal of Physical Therapy Science·Jae-Hwan ChoHae-Kag Lee
Oct 1, 1996·Journal of Epidemiology and Community Health·F ParazziniR Zecchin
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M T HannanD P Kiel
Nov 13, 2004·Breast Cancer Research : BCR·Chantal GuillemetteJohanie Lépine
Apr 11, 2001·Obstetrics and Gynecology Clinics of North America·J V ZborowskiJ A Cauley

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